Professor Bin Liu is Tan Chin Tuan Centennial Professor at the National University of Singapore (NUS). Bin graduated with a bachelor’s degree from Nanjing University and a Ph.D. in Chemistry from NUS. She had postdoctoral training at the University of California, Santa Barbara before joining NUS in late 2005. Bin has been well-recognized for her contributions to polymer chemistry and organic nanomaterials for energy and biomedical applications. She is an international member of the US National Academy of Engineering. She served as the Deputy Editor to launch and develop ACS Materials Letters (2019-2024), a flagship materials journal of the American Chemical Society. She is now an associate editor for the Journal of the American Chemical Society.
## 讲座简介
The recent years have witnessed the fast grow of fluorogens with aggregation-induced emission characteristics (AIEgens) in biomedical research. The weak emission of AIEgens as molecular species and their bright luminescence as nanoscopic aggregates distinguish them from conventional organic luminophores and inorganic nanoparticles, making them wonderful candidates for many high-tech applications. In this talk, we report our recent discovery of AIEgens exhibiting high brightness and efficient reactive oxygen species generation in the aggregate state and further demonstrate their potential in image-guided cancer surgery and therapy. By integrating accurate material performance predictions from first-principles calculations with Bayesian optimization-based active learning, we developed a self-improving discovery system for high-performance photosensitizers, significantly accelerating materials innovation in biomedical research.
Professor Tang Bo is an academician of the Chinese Academy of Sciences, a Leading Scientist at Laoshan Laboratory, a member of the Science and Technology Commission of the Ministry of Education, a member of the Chemistry Teaching Steering Committee, a Fellow of the Chinese Chemical Society, a Chief Scientist of the National Basic Research Program (973 Program), a recipient of the National Science Fund for Distinguished Young Scholars, and a member of the National Hundred, Thousand and Ten Thousand Talents Program. He leads the teaching and research team that was selected as one of the first“National University Huang Danian-style Teacher Teams.”Professor Tang’s research focuses on chemical imaging and sensing for life and health, development of analytical instruments, advanced photoresist and membrane separation materials, environmentally adaptive intelligent chemicals, and seawater hydrogen production. He has published over 500 significant papers as corresponding author (including co-corresponding) or first author in journals such as Nat. Synth., J. Am. Chem. Soc., Angew. Chem. Int. Ed. and Nat. Commun. His papers have been cited more than 59,000 times, with an H-index of 123. As the first inventor, he holds 113 authorized national invention patents, 11 of which have been transferred, and has received the National Invention and Entrepreneurship Award. He has been consecutively named an Elsevier Highly Cited Chinese Researcher for 11 years, and in 2024 received the ChemComm Outstanding Contribution Award from the Royal Society of Chemistry. As the principal investigator, he has won one second prize of the National Natural Science Award and two second prizes of the National Science and Technology Progress Award. He has led a number of national-level research projects, including the National Basic Research Program (973 Program), key projects of the National Natural Science Foundation of China, and the National Major Scientific Research Instrument Development Project of the National Natural Science Foundation of China.
Interfaces serve as organizational hubs in living systems—from material exchange barriers in organs and tissues, to nodes for intercellular recognition and signal integration, to energy-converting platforms on organelle membranes, and ultimately to receptor–ligand interactions at the molecular level. Across this multiscale hierarchy, interfaces collectively dictate homeostasis, signal transduction, and metabolic coupling. Consequently, chemical sensing and imaging that span this full spectrum of interfaces—from organs to molecules—are essential not only for unraveling the mechanisms underlying health and disease, but also for establishing rational design principles in synthetic biology and enabling the construction of artificial biological systems. Advancing such methodologies hinges on leveraging the quantum properties of electrons and photons as a foundational underpinning, and on integrating multimodal techniques including super-resolution fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, electrochemical imaging, and NV-center-based quantum sensing. By addressing key challenges such as the trade-off between penetration depth and resolution, the complexity of in vivo detection, and signal interference, this approach aims to establish a multiscale, multi-interface methodological framework that bridges microscopic quantum measurements with digital twin modeling, ultimately enabling precise regulation of life processes and rational design in synthetic biology.
