1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问,请联
系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
生物传感基础及 DNA 测序应用
Biosensor Basics and DNA Sequencing Application
2.
授课院系
Originating Department
深港微电子学院
School of Microelectronics
3.
课程编号
Course Code
SME314
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业选修课 Major Elective Courses
6.
授课学期
Semester
春季 Spring
7.
授课语言
Teaching Language
中英双语 English & Chinese
8.
他授课教师)
Instructor(s), Affiliation&
Contact
For team teaching, please list
all instructors
李毅 Yi Li
助理教授 深港微电子学院
Assistant Professor School of Microelectronics
liy37@sustech.edu.cn
9.
/助教系、
方式
Tutor/TA(s), Contact
NA
10.
选课人数限额(不填)
Maximum Enrolment
Optional
2
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
OtherPlease specify
总学时
Total
11.
学时数
Credit Hours
15
48
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
EE205 信号与系统或 CH101B 化学原理 B
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
14.
其它要求修读本课程的学系
Cross-listing Dept.
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
本课程旨在培养本科生在与生物医学/药物化学相关应用对接中芯片设计的兴趣与能力,主要分为三部分实施:1. 授芯片
界面的生化过程和互作机制;2. 讲授纳米技术对于芯片中电子输运的影响3. 生分组展示近年生物芯片的应用进展和新
机理。
This course aims to motivate the interests of students and foster their capability on designing biochips for biomedical
applications as well as medicines. It can be divided into the following three items: 1) Biochemical process and
interactions at the biochip interfaces, 2) Electronic transport with nanostructures and nanotechnology and 3) Group
presentation of recent processes on biochips.
16.
预达学习成果 Learning Outcomes
1、知悉生物芯片在个人医疗,分布式诊断和监护,对社会的影响力以及对于半导体芯片设计的需求
2、掌握生物化学过程在半导体界面相互作用的规律
3、掌握纳米技术对于电子输运的调制
4、学会设计和运用不同条件下的生物 CMOS 界面
1 Learn the basics of the influences of biochips on personal medicine, distributed diagnosis as well as monitoring;
Understand the design requirements for the semonconductor chips
2Master the rules of liquid/semiconductor interfaces upon biochemical processes
3Master the modulation of electron transport upon nanotechnology
4Learn to apply the knowledge onto the designs of Bio-CMOS interfaces under variant conditions
17.
课程内容及教学日历 (如授课语言以英文为主,则课程内容介绍可以用英文;如团队教学或模块教学,教学日历须注明
主讲人)
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
3
Section 1-2 Introduction. 1) Personal Bioelectronics; 2) Distributed Diagnostics and Personalized
Therapy; 3) Impact in Society 4) Need for New CMOS systems and 5) Aim of the course4 学时)
Section 3 案例分析:DNA 测序芯片 Case Study - DNA sequencing chips2 学时)
Section 4-5 电解液化学 Chemistry of Conductive solutions 4 学时)
Section 6 被测物和探针的生物化学过程 Biochemistry of Targets and Probes (1) 2 学时)
Section 7-8 被测物和探针的生物化学过程 Biochemistry of Targets and Probes (2) 4 学时)
Section 9 被测物与探针的相互作用(1Target/Probe interactions (1) 2 学时)
Section 10-11 被测物与探针的相互作用(2Target/Probe interactions (2) 4 学时)
Section 12 探针在界面的固定 Surface Immobilization of Probes (1) 2 学时)
Section 13-14 探针在界面的固定 Surface Immobilization of Probes (2) 4 学时)
Section 15 生物 CMOS 面的检测 Bio/CMOS Interfaces for Label-free Capacitance Sensing2
时)
Section 16-17 纳米技术用于阻挡电子输运 Nanotechnology to Prevent Electron Transfer4 学时)
Section 18 恒压下的生物 CMOS 界面 Bio/CMOS Interfaces in Constant Bias2 学时)
Section 19-20 纳米技术用于增强电子输运 Nanotechnology to Enhance Electron Transfer4 学时)
Section 21 电压扫描下的生物 CMOS 界面 Bio/CMOS Interfaces in Voltage Scan2 学时)
Section 22-23 学生分组展示(1Group Presentation 1/24 学时)
Section 24 学生分组展示(2Group Presentation 2/22 学时)
18.
教材及其它参考资料 Textbook and Supplementary Readings
参考资料 Reference
Bio/CMOS Interfaces and Co-design, Sandro Carrara, Springer 2013], ISBN9781461446897
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
出勤 Attendance
10
课堂表现
Class
30
4
Performance
小测验
Quiz
课程项目 Projects
30
平时作业
Assignments
0
期中考试
Mid-Term Test
0
期末考试
Final Exam
30
期末报告
Final
Presentation
其它(可根据需
改写以上评估方
式)
Others (The
above may be
modified as
necessary)
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制(通/不通过) Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/员会审议通过
This Course has been approved by the following person or committee of authority