1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问,请联
系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
医学免疫学 Medical Immunology
2.
授课院系
Originating Department
医学院 School of Medicine
3.
课程编号
Course Code
MED405
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业核心课 Major Core Courses
6.
授课学期
Semester
秋季/ Fall
春季/ Spring
7.
授课语言
Teaching Language
中英双语 English & Chinese
English with detailed explanation in Chinese on key terms
英文为主,难点增加中文解释
8.
他授课教师)
Instructor(s), Affiliation&
Contact
For team teaching, please list
all instructors
任欢,医学院;生物楼 B514; renh@sustech.edu.cn
REN Huan, School of Medicine; Rm B514, Biology Bldg.
9.
/
方式
Tutor/TA(s), Contact
NA
10.
选课人数限额(不填)
Maximum Enrolment
Optional
2
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
OtherPlease specify
总学时
Total
11.
学时数
Credit Hours
48
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
BIO102A ; BIO104 通生物学验;BIO320 子生学;BIO206-15
生物学
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
N/A
14.
其它要求修读本课程的学系
Cross-listing Dept.
N/A
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
《医学免疫学》是医学及相关专业主干基础课程,是专业核心课。该课程系统性阐述免疫系统的物质基础、诱发机体免疫
应答的抗原与危险信号、免疫应答的类型与作用、免疫病理以及免疫学相关应用在疾病诊断和防治中的作用。为学习其它
基础医学以及临床医学学科奠定重要基础。
Medical Immunology is a major core course for undergraduate students who major in Medicine and related subjects. The
course aims to help the students to understand components of the immune system, antigenic and danger signals that
stimulate the immune response, types of immune response, immunopathology and immune techniques and related
application in the clinics, etc. The course study will lay the foundation for the students to study other medical-related
courses.
16.
预达学习成果 Learning Outcomes
本课程完成后,学生将能够:
1)培养对机体的免疫系统组成及其功能的了解和认识;
2)培养对人体免疫系统在疾病发生发展中作用的认知视角;
3)掌握一定的免疫学分析方法和实践应用技能;了解免疫学规律在疾病预防及诊疗中的应用;
4)培养对免疫学与其它医学基础学科以及临床学科交叉知识的认识;
5)培养独立思考的能力和严谨求实的科学作风。
(1) Understand essential information on human immunology;
(2) Understand the role of a functional immune system in human lives and evolution;
(3) Grasp basic immune techniques and applications in disease treatment and prevention;
(4) Understand relationship and interdisciplinary knowledge between immunology and other medical sciences;
(5) Be trained on independent thinking, preciseness and factualism.
17.
课程内容及教学日历 (如授课语言以英文为主,则课程内容介绍可以用英文;如团队教学或模块教学,教学日历须注明
主讲人)
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course)
一、绪论
1. 医学免疫学发展史
2. 免疫系统功能、免疫器官与组织、免疫细胞与分子、免疫应答与病理性免疫
Part 1: General Introduction
1. Brief history, the development of Medical Immunology
2. General introduction to immunity, function of immune system, immune organs and tissue, immune cells and
molecules, immune response, immunopathogenesis
二、抗原
1. 概念与性质
2. 影响抗原免疫原性的因素
3
3. 分类及其在医学上的意义
4. 非特异性免疫刺激剂
Part 2: Antigen (Ag)
1. Definitions and properties
2. Factors that influence the immunogenicity of an Ag
3. Classification and application in medicine
4. Non-specific immune stimulator
三、免疫球蛋白
1. 概念和结构
2. 抗体的生物学特性与功能
3. 人工制备抗体
Part 3: Immunoglobulin (Ig)
1. Concept and structure Ig
2. Biological properties and functions of antibodies (Ab)
3. Human-made Ab
四、补体
1. 定义和组成成分
2. 补体的激活途径及其调节
3. 补体的生物学活性
4. 补体水平异常与疾病
Part 4: Complement system
1. Definition and components
2. Complement activation pathways and their regulation
3. Biological features
4. Complement abnormality and clinical diseases
五、细胞因子
1. 细胞因子分类和共同特性
2. 细胞因子受体
3. 细胞因子的免疫学作用与临床应用
Part 5: Cytokines
1. General introduction, common features and classification
2. Cytokine receptors
3. Immune function and clinical application
六、人类白细胞分化抗原和黏附分子
1. HLDA 概念与功能
2. 细胞黏附分子的分类与功能
3. 临床应用
Part 6: Human leukocyte differentiation Ag and cell adhesion molecules
1. Concept and function: HLDA
2. Cell adhesion molecules, classification and functions
3. Clinical application
七、主要组织相容性复合体
1. MHC 遗传特征
2. 人类白细胞抗原(HLA):分布、结构和功能
3. HLA 与临床疾病
Part 7: Major Histocompatibility Complex (MHC)
1. Human MHC genetic characteristics
2. Human leukocyte antigen (HLA): distribution, structures and function
3. HLA and clinical diseases
4
八、固有免疫系统与固有免疫应答
1. 固有免疫系统
2. 固有免疫细胞
3. 固有免疫识别
4. 固有免疫应答
Part 8: Innate immune system and innate immune response
1. Innate immune system
2. Innate immune cells
3. Innate immune recognition
4. Innate immune response
九、适应性免疫细胞
1. T 细胞发育
2. B 细胞发育
3. T/B 细胞表面分子与标记
4. T/B 细胞亚群、分类及其功能
Part 9: Adaptive immune cells
1. T cell development
2. B cell development
3. T cell surface molecules/ B cell surface molecules
4. T/B cell classifications and functions
十、抗原加工与提呈、抗原提呈细胞
1. 抗原提呈细胞
2. 经典抗原提呈途径
3. 非经典抗原提呈途径
Part 10: Antigen processing and presentation
1. Antigen presentation cells
2. Classical antigen presentation pathways
3. Non-classical antigen presentation pathways
十一、适应性免疫应答:细胞免疫应答
1. T 细胞识别特异性抗原
2. T 细胞活化、增殖分化和记忆细胞形成
3. 效应 T 细胞功能与适应性免疫应答转归
Part 11: Adaptive immune response: cellular immunity
1. T cell recognition of specific Ag
2. T cell activation, differentiation and memory
3. T cell effector function and outcomes
十二、适应性免疫应答:体液免疫应答
1. B 细胞识别特异性胸腺依赖性抗原(TD 抗原)
2. B 细胞对 TD 抗原的免疫应答
3. B 细胞对胸腺非依赖抗原(TI 抗原)的免疫应答
4. 体液免疫应答的一般规律
Part 12: Adaptive immune response: humoral immunity
1. B cell recognition of specific TD-Ag (Thymus-dependent Ag)
2. B cell mediated immune response against TD-Ag
3. B cell-mediated immune response against TI-Ag
4. General rules of humoral immune response
十三、免疫耐受
1. 免疫耐受概念
2. 中枢免疫耐受和外周免疫耐受
5
3. 免疫耐受的诱导
4. 免疫耐受的维护与意义
Part 13: Immune tolerance
1. Concept
2. Central tolerance and peripheral tolerance
3. Induction of immune tolerance
4. Maintain and significance of immune tolerance
十四、免疫调节
1. 概念与免疫调节的意义
2. 细胞水平的免疫调节
3. 分子水平的免疫调节
4. 器官与系统水平的免疫调节
Part 14: Immune regulation
1. Concept and significance of immune regulation
2. Immune regulation at the molecular level
3. Immune regulation at the molecular level
4. Immune regulation at the systemic level and others
十五、免疫紊乱:超敏反应(案例讨论+演讲)
1. 四型超敏反应特征、过敏反应机制与案例
2. II 型超敏反应机制与案例
3. III 型超敏反应机制与案例
4. IV 型超敏反应机制与案例
Part 15: Immune related disorder: hypersensitivity case discussion + oral presentation
1. General introduction, allergy and cases
2. Type II hypersensitivity and cases
3. Type III hypersensitivity and cases
4. Type IV hypersensitivity, summary
十六、免疫病理:相关疾病
1. 免疫缺陷病
2. 自身免疫病
3. 移植免疫
4. 肿瘤免疫
Part 16: Immune related disease
1. Immunodeficiency diseases
2. Autoimmune diseases
3. Transplantation immunology
4. Immunity to Tumor
十七、免疫学诊断与免疫调控
1. 免疫学技术
2. 免疫预防
3. 免疫治疗
Part 17: Immunodiagnosis and Immune manipulation
1. Immunological technology
2. Immunoprophylaxis
3. Immunotherapy
Quiz, Review & discussions, Presentations interspersed throughout the semester
Section
Hour
Teaching Contents
6
绪论 &免疫器官与组织
1
3
Introduction & Immune organs and tissues
抗原
2
3
antigens
免疫球蛋白-I
3
3
Immunoglobulins-I, structure and functions; classification and properties
免疫球蛋白-II1 h
human-made Abs
4
3
补体系统 2 h
Complement systems
细胞因子
Cytokines
人类白细胞分化抗原和黏附分子
5
3
Human leukocyte differentiation Ag and cell adhesion molecules
主要组织相容性复合体
6
3
Major Histocompatibility Complex (MHC)
固有免疫系统与固有免疫应答
7
3
Innate immune system and innate immune response
适应性免疫细胞
8
3
Adaptive immune cells
抗原加工与提呈,抗原提呈细胞
9
3
Ag processing and presentation, antigen presentation cells
适应性细胞免疫应答
10
3
Adaptive immunity: cell-mediated immune response
适应性体液免疫应答
11
3
Adaptive immunity: humoral immune response
免疫耐受与免疫调节
12
3
Immune tolerance and regulation
免疫紊乱-I I 型超敏反应 (分组讨论与演讲 1)
13
3
Immune disorder-I (type I hypersensitivity) project and presentation1
免疫紊乱-II IIIIIIV 型超敏反应(分组讨论与演讲 2
14
3
Immune disorder-II (type II, III, IV hypersensitivity) project and presentation 2
免疫病理
15
3
Immune-related diseases
免疫学诊断与治疗+期末复习
16
3
Immune diagnosis and therapy + final review
18.
教材及其它参考资料 Textbook and Supplementary Readings
Textbooks:
Cellular and Molecular Immunology (9th edition). Abul K. Abbas, Andrew H. Lichtman and Shiv Pillai. ELSEVIER.
曹雪涛主编《医学免疫学》 7 2018 年,人民卫生出版社
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
出勤 Attendance
10
7
课堂表现
Class
Performance
小测验
Quiz
10
课程项目 Projects
10
平时作业
Assignments
10
期中考试
Mid-Term Test
20
期末考试
Final Exam
40
期末报告
Final
Presentation
其它(可根据需
改写以上评估方
式)
Others (The
above may be
modified as
necessary)
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制(通/不通过) Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/员会审议通过
This Course has been approved by the following person or committee of authority
本课程已经医学院教学副主任张文勇教授审核通过。