1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问，请
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be directed
to the course instructor.
1.
课程名称 Course Title
肿瘤生物学原理 Cancer Biology Principles
2.
授课院系
Originating Department
医学院 School of Medicine
3.
课程编号
Course Code
MED333
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业选修课/ Major Elective Course
6.
授课学期
Semester
春季/ Spring
7.
授课语言
Teaching Language
中英双语 English & Chinese
8.
授课教师、所属学系、联系方
式（如属团队授课，请列明其
他授课教师）
Instructor(s), Affiliation&
Contact
（For team teaching, please list
all instructors）
董金堂，医学院，人类细胞生物和遗传学系，dongjt@sustech.edu.cn
Jintang Dong, School of Medicine, Department of Human Cell Biology and Genetics,
dongjt@sustech.edu.cn
9.
实验员/助教、所属学系、联系
方式
Tutor/TA(s), Contact
10.
选课人数限额(可不填)
Maximum Enrolment
（Optional）
2
11.
讲授
Lectures
习题/辅导/讨论
Tutorials
平时考试/
Regular tests
期末考试/Final exam
总学时
Total
42
1
3
2
48
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
无/NA
13.
后续课程、其它学习规划
Courses for which this
course is a pre-requisite
待定/To be determined
14.
其它要求修读本课程的学系
Cross-listing Dept.
待定/To be determined
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
肿瘤是危害人类健康的重大疾病之一，肿瘤研究几十年以来一直是生命科学和医学研究的重大
和热点领域之一。本课程的教学目标为：
（1）获得对肿瘤这类疾病的认识，包括发病情况、对社会的影响、组织病理和临床特点、诊断和治
疗等方面的基本概念和原理。
（2）掌握肿瘤生物学的基本知识，了解各个主要方面的内容，包括肿瘤细胞的各种特点、肿瘤信号
通路、肿瘤细胞的代谢、肿瘤免疫、分子诊断、衰老和癌症、肿瘤预防和治疗等。
（3）获得并加强对肿瘤各主要方面的兴趣，拓宽学术视野，为将来进行相关研究和临床工作打好基
础。
Cancer is one of the major health problems, and cancer research has been one of the major areas of
biomedical sciences. The teaching objectives of this course are:
(1) To gain knowledge of cancer, including its incidence and impact on society, histopathological
and clinical features, and the concepts and principles behind the diagnosis and treatment of cancers.
(2) To Grasp basic knowledge of cancer biology and understand the main research aspects of
cancer biology, including various cellular characteristics, cancer cell signaling pathways, cancer
cell metabolism, tumor immunology, tumorigenesis, molecular diagnosis, aging and cancer, and
cancer prevention and treatment etc.
(3) To gain and/or strengthen the interest in cancer, broaden the vision for biomedical sciences, and
lay the foundation for future career in research or clinical work targeting cancer.
16.
预达学习成果 Learning Outcomes
通过本课程的学习，预期将获得对肿瘤作为一类疾病的基本认识（发病情况、其对社会的影
响、其诊断和治疗等方面的基本概念和原理等）；掌握肿瘤生物学的概念和原理并了解各主要方面
的内容，包括肿瘤细胞的各种特点、肿瘤信号通路、肿瘤细胞的代谢、肿瘤免疫、分子诊断、衰老
和癌症、肿瘤预防和治疗等等；获得或强化对肿瘤各主要方面的兴趣，为将来进行相关研究或临床
工作打下基础。
By completing this course, students will gain knowledge of cancer and its impact on society, and the
concepts and principles behind the diagnosis and treatment of various cancers; Grasp basic
knowledge of cancer biology in the major areas, including various cellular characteristics, cancer
cell signaling pathways, cancer cell metabolism, tumor immunology, tumorigenesis, molecular
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diagnosis, aging and cancer, and cancer prevention and treatment etc.; and Gain and/or strengthen
the interest in cancer research or clinical work on cancer in the future.
17.
课程内容及教学日历 （如授课语言以英文为主，则课程内容介绍可以用英文；如团队教学或模块教学，教学日历须注明
主讲人）
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
Each section takes 3 hours to finish. The 5
th
, 10
th
and 15
th
sections include a one-hour test for
contents from the previous sections.
每个部分需要三小时完成。第 5、10 和 15 部分包括一个 60 分钟的考试，考前面几次的学习
内容。
Section 1/第 1 部分
Cancer: incidence, mortality, histopathologic and clinical features, and biological hallmarks
癌症发生率、死亡率、组织病理和临床特点以及生物学特征
Section 2/第 2 部分
Cancer cell immortalization, proliferation, and survival
癌细胞永生化、增殖和生存
Section 3/第 3 部分
Oncogenes
癌基因
Section 4/第 4 部分
Tumor suppressor genes
肿瘤抑制基因
Section 5/第 5 部分
Causes of cancer, DNA damage and repair, and genetic/epigenetic alterations
癌症的起因、DNA 损伤修复以及遗传与表观遗传改变
Section 6/第 6 部分
Chemical carcinogenesis and multistep and multifactor nature of cancer
化学癌变以及癌症的多步骤多阶段特点
Section 7/第 7 部分
Physical and biological carcinogenesis
物理和生物因子诱导的癌变
Section 8/第 8 部分
Hereditary factors in cancer development
癌症发生的遗传因素
Section 9/第 9 部分
Invasion and cancer metastasis
浸润和肿瘤转移
4
Section 10/第 10 部分
Tumor microenvironment and immune evasion
肿瘤微环境和免疫逃逸
Section 11/第 11 部分
Omics and cancer signaling network
组学和肿瘤信号网络
Section 12/第 12 部分
Stem cells and the cellular origin of cancer
干细胞和癌症的细胞起源
Section 13/第 13 部分
Other hallmarks of cancer – angiogenesis and cancer metabolism
癌的其他特征：血管新生和癌细胞代谢
Section 14/第 14 部分
Cancer screening, diagnosis, and treatment
癌症的筛查、诊断和治疗
Section 15/第 15 部分
Cancer prevention
癌症预防
Section 16
Review and discussion, 1 hour; Final exam, 2 hours
复习与讨论，1 小时；期末考试，2小时
Section
Topic
Hours
1
Cancer: incidence, mortality, histopathologic and clinical features, and biological hallmarks
癌症发生率、死亡率、组织病理和临床特点以及生物学特征
3
2
Cancer cell immortalization, proliferation, and survival
癌细胞永生化、增殖和生存
3
3
Oncogenes
癌基因
3
4
Tumor suppressor genes
肿瘤抑制基因
3
5
Causes of cancer, DNA damage and repair, and genetic/epigenetic alterations
癌症的起因、DNA损伤修复以及遗传与表观遗传改变
3
6
Chemical carcinogenesis and multistep and multifactor nature of cancer
化学癌变以及癌症的多步骤多阶段特点
3
7
Physical and biological carcinogenesis
物理和生物因子诱导的癌变
3
8
Hereditary factors in cancer development
癌症发生的遗传因素
3
5
9
Invasion and cancer metastasis
浸润和肿瘤转移
3
10
Tumor microenvironment and immune evasion
肿瘤微环境和免疫逃逸
3
11
Omics and cancer signaling network
组学和肿瘤信号网络
3
12
Stem cells and the cellular origin of cancer
干细胞和癌症的细胞起源
3
13
Other hallmarks of cancer – angiogenesis and cancer metabolism
癌的其他特征：血管新生和癌细胞代谢
3
14
Cancer screening, diagnosis, and treatment
癌症的筛查、诊断和治疗
3
15
Cancer prevention
癌症预防
3
16
Review and discussion, 1 hour; Final exam, 2 hours
复习与讨论，1小时；期末考试，2小时
3
教材及其它参考资料 Textbook and Supplementary Readings
教材/Textbooks：
1. Kleinsmith LJ (2014) Principles of Cancer Biology - Pearson New International Edition. Pearson Education Limited,
London, UK..
2. Weinberg RA (2014) The Biology of Cancer. Willey and Sons, New York.
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
出勤 Attendance
2
课堂表现
Class
Performance
4
小测验
Quiz
课程项目 Projects
平时作业
Assignments
期中考试
Mid-Term Test
期末考试
Final Exam
120 min/120 分钟
40
期末报告
Final
Presentation
6
其它（可根据需要
改写以上评估方
式）
Others (The
above may be
modified as
necessary)
第 5 周考试
Test in the 5
th
week
50 min/50 分钟
第 10 周考试
Test in the 10
th
week
50 min/50 分钟
第 15 周考试
Test in the 15
th
week
50 min/50 分钟
18
18
18
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制（通过/不通过） Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/委员会审议通过
This Course has been approved by the following person or committee of authority
本课程已经医学院教学副院长张文勇教授审核通过。