1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问,请联
系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
医学生物化学 Medical Biochemistry
2.
授课院系
Originating Department
医学院 School of Medicine
3.
课程编号
Course Code
MED203
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业基础课 Major Foundational Courses
6.
授课学期
Semester
秋季 / Fall
7.
授课语言
Teaching Language
中英双语 English & Chinese
8.
他授课教师)
Instructor(s), Affiliation&
Contact
For team teaching, please list
all instructors
刘泉,副教授,南方科技大学医学院
liuq3@sustech.edu.cn
0755-88018055
Quan Liu, Associate Professor, School of Medicine, Southern University of Science and
Technology
Email: liuq3@sustech.edu.cn
0755-88018055
9.
/
方式
Tutor/TA(s), Contact
NA
10.
选课人数限额(不填)
Maximum Enrolment
2
Optional
授课方式
Delivery Method
讲授
Lectures
实验/实习
Lab/Practical
其它(请具体注明)
OtherPlease specify
总学时
Total
11.
学时数
Credit Hours
45
0
2 ( /mid-term
exam)
48
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
None
14.
其它要求修读本课程的学系
Cross-listing Dept.
None
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
生物化学是临床医学专业的基础课、必修课。课程目标是培养临床医生。基于这个根本目标,本课程将以人类
疾病和临床应用为导向,阐述生物体内物质的化学组成、结构和功能。通过本课程的学习,使医学生能够理解
并掌握生物化学的基本知识和基本理论,最终学会应用这些知识和理论来指导解决临床相关问题。
Biochemistry is a required basis course for clinical medicine, with the aim to train future physicians. According to this, this
course is guided by clinical application and designed to shed light on the chemical substances in an organism, and their
structures and functions. With this course, medical students will learn basic knowledge and theories of biochemistry and
finally achieve the capability in dealing with clinical problems with these principles of biochemistry.
16.
预达学习成果 Learning Outcomes
1)系统性地掌握人体正常、稳态及疾病、非稳态的功能与调节机制。
Systemically understand human physiological functions and regulatory mechanisms under normal/stable and
disease/unstable states.
2)生物大分子的结构、功能和二者之间的关系。
Structure and function of biomolecules and the relationship between them.
3)糖、脂、蛋白、核苷酸的代谢及其调节。
Metabolism of carbohydrates, lipids, proteins and nucleotides, and it’s regulation.
4)维生素、钙、磷、微量元素等生物分子的特点。
Features of vitamins, calcium, phosphorus, and trace elements.
5)血液和肝脏的生物化学特点。
Features of blood and liver biochemistry.
17.
课程内容及教学日历 (如授课语言以英文为主,则课程内容介绍可以用英文;如团队教学或模块教学,教学日历须注明
讲人)
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if this is a
team teaching or module course.)
None
3
第一章 绪论
Chapter 1 Introduction
一、生物化学发展简史
A brief history of biochemistry
二、生物化学的基础
Foundation of biochemistry
三、当代生物化学研究的主要内容
Areas of contemporary biochemical research
第二章 蛋白质的结构与功能
Chapter 2 Structure and function of proteins
一、蛋白质的分子组成与结构
Molecular composition and function of proteins
二、蛋白质结构与功能的关系
Association of protein structure and function
三、蛋白质的理化性质
Physicochemical properties of proteins
第三章 核酸的结构与功能
Chapter 3 Structure and function of nucleic acids
一、核酸的分子组成与一级结构
Molecular composition and primary structure of nucleic acids
二、DNA 的空间结构与功能
3-dimensional structure and function of DNA
三、RNA 的空间结构与功能
3-dimensional structure and function of RNA
四、核酸的理化性质
Physicochemical properties of proteins nucleic acids
第四章 酶与酶促反应
Chapter 4 Enzymes and enzyme-catalyzed reactions
一、酶的分子结构与功能
Molecular composition and function of enzymes
二、酶的工作原理
Principles of enzyme functions
三、酶促反应动力学
Kinetics of enzyme-catalyzed reactions
四、酶的调节
Regulation of enzymes
五、酶的分类与命名
4
Classification and nomenclature of enzymes
六、酶在医学中的应用
Application of enzymes in medicine
第五章 聚糖的结构与功能
Chapter 5 Structure and function of glycans
一、糖蛋白分子中聚糖及其合成过程
Glycans in glycoproteins and their synthesis
二、蛋白聚糖分子中的糖胺聚糖
Glycosaminoglycans in proteoglycans
三、糖脂的组成
The composition of glycolipids
四、聚糖结构中的生物信息
Bioinformation in the structure of glycans
第六章 糖代谢
Chapter 6 Metabolism of carbohydrates
一、糖的摄取与利用
Uptake and utilization of carbohydrates
二、糖的无氧氧化
Anaerobic oxidation of glucose
三、糖的有氧氧化
Aerobic oxidation of glucose
四、磷酸戊糖途径
Pentose phosphate pathway
五、糖原的合成与分解
Glycogenesis and glycogenolysis
六、糖异生
Gluconeogenesis
七、葡萄糖的其它代谢途径
Other pathways of glucose metabolism
八、血糖及其调节
Blood glucose and its regulation
第七章 生物氧化
Chapter 7 Biological oxidation
一、线粒体氧化体系与呼吸链
Oxidation in mitochondria and respiratory chain
二、氧化磷酸化与 ATP 生成
Oxidative phosphorylation and ATP synthesis
三、氧化磷酸化的影响因素
Factors that affect oxidative phosphorylation
5
四、其它氧化与抗氧化体系
Other oxidation and anti-oxidation systems
第八章 脂质代谢
Chapter 8 Metabolism of lipids
一、脂质的构成、功能及分析
Composition, function and analysis of lipids
二、脂质的消化与吸收
Digestion and absorption of lipids
三、甘油三酯代谢
Metabolism of triglyceride
四、磷脂代谢
Metabolism of phosholipids
五、胆固醇代谢
Metabolism of cholesterol
六、血浆脂蛋白及其代谢
Plasmic lipoproteins and their metabolism
第九章 蛋白质消化吸收和氨基酸代谢
Chapter 9 Digestion and absorption of protein and metabolism of amino acids
一、蛋白质的营养价值与消化吸收
Nutrition value, digestion and absorption of proteins
二、氨基酸的代谢
Metabolism of amino acids
三、氨的代谢
Metabolism of amine
四、个别氨基酸的代谢
Metabolism of specific amino acids
第十章 核苷酸代谢
Chapter 10 Metabolism of nucleotides
一、核苷酸代谢概述
Introduction
二、嘌呤核苷酸的合成与分解代谢
Anabolism and catabolism of purine nucleotides
三、嘧啶核苷酸的合成与分解代谢
Anabolism and catabolism of pyrimidine nucleotides
第十一章 代谢的整合与调节
Chapter 11 Integration and regulation of metabolism
一、代谢的整体性
Integrity of metabolism
6
二、代谢调节的主要方式
Major mechanisms of metabolic regulation
三、体内重要组织和器官的代谢特点
Metabolic features of major tissues and organs
第十二章 肝脏的生物化学
Chapter 12 Liver biochemistry
一、肝在物质代谢中的作用
Metabolic roles of the liver
二、肝的生物转化作用
Biotransformation in the liver
三、胆汁与胆汁酸的代谢
Metabolism of bile and bile acid
四、胆色素的代谢与黄疸
Metabolism of bile pigment and jaundice
第十三章 维生素
Chapter 13 Vitamins
一、脂溶性维生素
Lipid-soluble vitamins
二、水溶性维生素
Water-soluble vitamins
第十四章 钙、磷及微量元素
Chapter 14 Calcium, phosphorus and trace elements
一、钙、磷代谢
Metabolism of calcium and phosphorus
二、微量元素
Trace elements
Wee
k
Hour
Teaching Contents
1
3
绪论
Introduction
2
3
蛋白质的结构与功能
Structure and function of proteins
3
3
核酸的结构与功能
Structure and function of nucleic acids
4
3
酶与酶促反应
Enzymes and enzyme-catalyzed reactions
5
3
聚糖的结构与功能
Structure and function of glycans
6
3
糖代谢 1
Metabolism of carbohydrates 1
7
3
糖代谢 2