课程大纲
COURSE SYLLABUS
1.
课程代码/名称
Course Code/Title
生态毒理学
Ecotoxicology
2.
课程性质
Compulsory/Elective
专业选修课
Professional Elective Courses
3.
开课单位
Offering Dept.
环境科学与工程学院
School of environmental science and Engineering
4.
课程学分/学时
Course Credit/Hours
3/48
5.
授课语言
Teaching Language
中英双语
English & Chinese
6.
授课教师
Instructor(s)
裘文慧
7.
开课学期
Semester
春季
Spring
8.
是否面向本科生开放
Open to undergraduates
or not
否
No
9.
先修要求
Pre-requisites
无
None
10.
教学目标
Course Objectives
本课程以生态层次为纲、环境污染物为主线，重点讲授环境污染物对动物、植物、微生物及其生态系
统的毒性效应、毒性作用机理以及生态风险评价方法，使学生理解外来化合物与自然环境之间的相互
作用关系，拓张对环境毒性的认识视野；了解生态系统内毒物的来源、传播和归宿，掌握生态毒理学
检测和监测的基本途径和方法；利用生态毒理学的知识应对环境污染生态防治，将理论与实际结合起
来。
The course of “Ecotoxicology” focuses on the toxic effects, toxic mechanism and ecological risk assessment
methods of environmental pollutants on animals, plants, microorganisms and their ecosystems, so as to enable
students to understand the interaction between foreign compounds and the natural environment and expand
their understanding of environmental toxicity; Understand the source, transmission and destination of poisons
in the ecosystem, and master the basic ways and methods of ecotoxicological detection and monitoring; Use
the knowledge of ecotoxicology to deal with the ecological prevention and control of environmental pollution,
and combine theory with practice.
11.
教学方法
Teaching Methods
授课方式
Teaching Method
讲授
Lectures
实验/实习
Lab/Practical
其它(请具体注
明)
Other（Please
specify）
总学时
Total
学时数
Credit Hours
40
0
0
48
12.
教学内容
Course Contents
Section 1
生态毒理学的概论
Introduction to ecotoxicology
概述生态毒理学，生态毒理学的发展历史和展望，生态毒理学的基本研
究方法
This chapter summarizes ecotoxicology, the development history and Prospect
of ecotoxicology, and the basic research methods of ecotoxicology
Section 3
环境与环境污染物
Environment and environmental pollution
概述环境与环境污染，环境污染物的概念和分类
This chapter summarizes the environment and environmental pollution, the
concept and classification of environmental pollutants
Section 4
环境污染与生态系统
Environment pollution and ecosytems
概述生态因子及其作用特征，生物种、种群及群落，生态系统及其特征
This chapter summarizes ecological factors and their action characteristics,
biological species, populations and communities, ecosystems and their
characteristics
Section 5
毒性作用的主要概念与类型
Main concepts and types of toxic effects
概述毒性作用，毒性作用的类型，联合毒性作用
This section summarizes toxic effects, types of toxic effects, and combined
toxic effects
Section 6
毒性作用的机制及影响因素
Mechanism and factors of toxic effects
综述毒性作用的机制，包括毒性物质干扰正常受体配体的相互作用，细
胞膜损伤，干扰细胞内钙稳态和细胞能量的产生，自由基与氧化损伤，
概述影响毒性作用的因素
This chapter summarizes the mechanisms of toxicity, including toxic
substances interfering with the interaction of normal receptor ligands, cell
membrane damage, interfering with intracellular calcium homeostasis and cell
energy production, free radicals and oxidative damage, and summarizes the
factors affecting toxicity
Section 7
基于课程主题“环境污染与生态系统”的小组汇报讨论
Group report and discussion based on the subject of the environmental
pollution and ecosystem
学生关于“环境污染与生态系统”进行自主讨论
An independent discussion on "environmental pollution and ecosystem"
between students
Section 8
生物膜的结构与环境污染物的生物转运
Structure of biofilm and biological transport of environmental pollutants
概述生物膜的结构和功能，生物转运的方式，环境污染物的吸收、分布
及排泄
This paper summarizes the structure and function of biofilm, the mode of
biological transport, and the absorption, distribution and excretion of
environmental pollutants
Section 9
环境污染物在体内的生物转化
Biotransformation of environmental pollutants in vivo
概述环境污染物的生物转化的反应类型和影响生物转化的因素
This chapter summarizes the reaction types of biotransformation of
environmental pollutants and the factors affecting biotransformation
Section 10
生物富集
Bioconcentration
概述生物富集的概念，生物富集的过程
This chapter summarizes the concept of bioconcentration and the process of
bioconcentration
Section 11
生物富集动力学
Bioaccumulation kinetics
综述吸附动力学，生物富集动力学
This chapter summarizes adsorption kinetics and bioconcentration kinetics
Section 12
影响生物富集的因素
Factors of bioaccumulation
概述环境污染物的物理化学性质，生物特性，环境因素
This chapter summarizes the physical and chemical properties, biological
characteristics and environmental factors of environmental pollutants
Section 13
生物放大研究技术
Biomagnification research technology
概述生物放大的生态毒理学意义，金属和类金属的生物放大，有机化合
物的生物放大，生物放大研究技术
This chapter summarizes the ecotoxicological significance of
biomagnification, biomagnification of metals and metalloids, biomagnification
of organic compounds and biomagnification research technology
Section 14
基于课程主题“环境污染物的生物转化和转运”的小组汇报讨论
Group report and discussion based on the subject of the biotransformation and
transport of environmental pollutants
学生关于“环境污染物的生物转化和转运”进行自主讨论
An independent discussion on " the biotransformation and transport of
environmental pollutants " between students
Section 15
环境污染物生态毒性作用的特点
Characteristics of ecotoxicity of environmental pollutants
概述环境污染物生态毒性的作用特点
This chapter summarizes the characteristics of ecotoxicity of environmental
pollutants
Section 16
分子水平的生态毒理学效应
Ecotoxicological effects at molecular level
概述环境污染物的酶效应，DNA 损伤，蛋白合成诱导，氧化应激和抗氧
化状态，对卟啉合成的影响
This chapter summarizes the enzymatic effects of environmental pollutants,
DNA damage, protein synthesis induction, oxidative stress and antioxidant
status, and their effects on porphyrin synthesis
Section 17
细胞、组织及器官水平的生态毒理学效应
Ecotoxicological effects at cell, tissue and organ levels
概述细胞水平的生态毒理学效应，亚细胞水平的生态毒理学效应，细胞
突变与癌变，组织、器官水平的生态毒理学效应
This chapter summarizes ecotoxicological effects at the cellular level,
ecotoxicological effects at the subcellular level, cell mutation and
carcinogenesis, and ecotoxicological effects at the tissue and organ levels
Section 18
个体水平的生态毒理学效应
Ecotoxicological effects at the individual level
概述亚致死效应，致死效应，影响致死效应的因素
This chapter summarizes sublethal effect, lethal effect and factors affecting
lethal effect
Section 19
种群、群落及生态系统水平的生态毒理学效应
Ecotoxicological effects at the level of population, community and ecosystem
概述环境污染物对种群的影响，环境污染对生物群落的影响，环境污染
对生态系统的影响
This chapter summarizes the impact of environmental pollutants on
populations, the impact of environmental pollution on biological communities,
and the impact of environmental pollution on ecosystems
Section 20
基于课程主题“环境污染物的生态毒理学效应”的小组汇报讨论
Group report and discussion based on the subject of the ecotoxicological
effects of environmental pollutants
学生关于“环境污染物的生态毒理学效应”进行自主讨论
An independent discussion on "the ecotoxicological effects of environmental
pollutants" between students
Section 21
动物对环境污染物的吸收、发布、排泄及转化
Absorption, release, excretion and transformation of environmental pollutants
by animals
概述动物对环境污染物的吸收，分布与贮存，环境污染物的排泄，环境
污染物的生物转化
This chapter summarizes the absorption, distribution and storage of
environmental pollutants by animals, the excretion of environmental pollutants
and the biotransformation of environmental pollutants
Section 22
环境污染物对动物的生态毒理学效应及机制
Ecotoxicological effects and mechanisms of environmental pollutants on
animals
综述环境污染物对动物生态毒性的主要类型，主要毒性机制
This chapter summarizes the main types and main toxicity mechanisms of
environmental pollutants to animals
Section 23
人工饲养动物生态毒理学
Ecotoxicology of captive animals
概述有毒植物和微生物引起的中毒，化学物引起的中毒
Poisoning caused by poisonous plants and microorganisms, and poisoning
caused by chemicals
Section 24
基于课程主题“动物生态毒理学效应”的小组汇报讨论
Group report and discussion based on the subject of the ecotoxicological
effects of animals
学生关于“动物生态毒理学效应”进行自主讨论
An independent discussion on "the ecotoxicological effects of animals"
between students
13.
课程考核
Course Assessment
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分
比
% of final
score
违纪处罚
Penalty
备注
Notes
√
出勤 Attendance
每周 Every Week
10%
√
课堂表现
Class
Performance
每周 Every Week
40%
小测验
Quiz
课程项目
Projects
√
平时作业
Assignments
16 周
Week 16
20%
期中考试
Mid-Term Test
期末考试
Final Exam
√
期末报告
Final
Presentation
16 周
Week 16
30%
其它（可根据需
要改写以上评估
方式）
Others (The
above may be
modified as
necessary)
14.
教材及其它参考资料
Textbook and Supplementary Readings
教材 Textbook
[1]《生态毒理学》，孟紫强，高等教育初版社，2009 年初版
《Ecotoxicology》, Meng, Z. Q, Higher Education Publishing House, 2009
参考资料 Supplementary Readings
[2]《生态毒理学与案例分析》，张杭君，化学工业初版社，2021 年 9 月初版
《Ecotoxicology and case analysis》, Zhang, H. J, Chemical Industry Publishing House, September 2021
[3]《Fundamentals of Ecotoxicology》，Newman, M.C, Unger, M.A, Fundamentals of Ecotoxicology, 2002
(英文参考书)
[4] 《Fish Ecotoxicology》, Braunkberk, T, Hinton, D.E, SPRINGER, 2012)（英文参考书）