课程大纲
COURSE SYLLABUS
1.
课程代码/名称
Course Code/Title
持久性有机污染物的环境健康效应
Environmental health effects of persistent organic pollutants
2.
课程性质
Compulsory/Elective
专业选修课
Professional Elective Courses
3.
开课单位
Offering Dept.
环境科学与工程学院
School of environmental science and Engineering
4.
课程学分/学时
Course Credit/Hours
2/32
5.
授课语言
Teaching Language
中英双语
English & Chinese
6.
授课教师
Instructor(s)
裘文慧
7.
开课学期
Semester
秋季
Fall
8.
是否面向本科生开放
Open to undergraduates
or not
否
No
9.
先修要求
Pre-requisites
无
None
10.
教学目标
Course Objectives
本课程的目标是使学生熟悉持久性有机污染物与环境健康之间的相互联系，增强学生保护环境的意
识。通过本课程的学习，使学生了解持久性有机污染物的环境行为特征，以及持久性有机污染物从环
境介质进入生物体的方式和途径；熟悉持久性有机污染物对生物体包括人体健康的影响及其影响机
理，从个体到细胞和分子水平解释持久性有机污染物与健康的响应关系。本课程力图通过系统性和生
动性的知识讲授，使学生掌握基本的环境和健康的科学知识，培养基本的环境科学素养和环境保护意
识。
The goal of the course of “Environmental health effects of persistent organic pollutants” is to make students
familiar with the relationship between persistent organic pollutants and environmental health, and enhance
students' awareness of environmental protection. Through the study of this course, students can understand the
environmental behaviour characteristics of persistent organic pollutants and the ways and means of persistent
organic pollutants entering organisms from environmental media; Be familiar with the impact of persistent
organic pollutants on organisms including human health and its impact mechanism, and explain the response
relationship between persistent organic pollutants and health from individual to cellular and molecular level.
Through systematic and vivid knowledge teaching, this course aims to enable students to master basic
environmental and health scientific knowledge and cultivate basic environmental scientific literacy and
environmental protection awareness.
11.
教学方法
Teaching Methods
授课方式
Teaching Method
讲授
Lectures
实验/实习
Lab/Practical
其它(请具体注
明)
Other（Please
specify）
总学时
Total
学时数
Credit Hours
22
0
0
32
12.
教学内容
Course Contents
Section 1
持久性有机污染物（POPs）的生态毒理学研究历程与进展
Research process and progress of ecotoxicology of persistent organic
pollutants (POPs)
简述 POPs 生态毒理学的研究历程和研究进展，展望 POPs 生态毒理与健
康效应研究的发展趋势
This chapter briefly describes the research process and progress of POPs
ecotoxicology, and looks forward to the development trend of POPs
ecotoxicology and health effects
Section 2
化学物质剂量效应关系
Dose effect relationship of chemical substances
概述化学物质的剂量-效应关系，剂量-效应曲线模型，剂量-效应的置信
区间
This chapter summarizes the dose-effect relationship of chemicals, dose-effect
curve model and dose-effect confidence interval
Section 3
联合毒性效应
Combined toxic effect
概述混合物的加和参考模型，重点评估混合物的毒性
This chapter summarizes the addition and reference model of the mixture,
focusing on the evaluation of the toxicity of the mixture
Section 4
POPs 的生物吸收和转化
Bioabsorption and transformation of POPs
概述 POPs 的生物吸收和转运，生物转化和代谢，生物富集过程，POPs
的生物有效性，沿食物链的迁移
This chapter summarizes the bioabsorption and transport of POPs,
biotransformation and metabolism, bioconcentration process, bioavailability of
POPs, and migration along the food chain
Section 5
POPs 的遗传毒性
Genotoxicity of POPs
概述 POPs 的遗传毒性，POPs 导致的遗传物质损伤，氯酚类污染物诱发
基因点突变的效应研究，多世代毒性效应
This chapter summarizes the genotoxicity of POPs, genetic material damage
caused by POPs, the effect of chlorophenols on gene point mutation, and multi
generation toxicity
Section 6
基于课程主题“POPs 遗传毒性”的小组汇报讨论
Group report and discussion based on the subject of the geneotoxicity of POPs
学生关于“POPs 遗传毒性”进行案例讨论
An independent case discussion on "the geneotoxicity of POPs " between
students
Section 7
POPs 的生殖发育毒性
Reproductive and developmental toxicity of POPs
POPs 对生殖能力的影响，POPs 的致畸性，POPs 对生物发育进程的影响
This chapter summarizes the impact of POPs on reproductive ability,
teratogenicity of POPs and the impact of POPs on biological development
process
Section 8
基于课程主题“POPs 生殖发育毒性”的小组汇报讨论
Group report and discussion based on the subject of the reproductive and
developmental toxicity of POPs
学生关于“POPs 的生殖发育毒性”进行案例讨论
An independent case discussion on "the reproductive and developmental
toxicity of POPs" between students
Section 9
POPs 的神经发育毒性
Neurodevelopmental toxicity of POPs
概述 POPs 的神经毒性，体外研究中 POPs 的神经细胞毒性，POPs 的神
经行为毒理学效应，POPs 的神经发育毒性
This chapter summarizes the neurotoxicity of POPs, the neurocytotoxicity of
POPs in vitro, the neurobehavioral toxicological effects of POPs, and the
neurodevelopmental toxicity of POPs
Section 10
基于课程主题“POPs 神经发育毒性”的小组汇报讨论
Group report and discussion based on the subject of the neurodevelopmental
toxicity of POPs
学生关于“POPs 的神经发育毒性”进行案例讨论
An independent case discussion on "the neurodevelopmental toxicity of POPs
" between students
Section 11
POPs 的免疫毒性
Immunotoxicity of POPs
综述免疫毒理学的定义和发展，免疫毒性的评价和作用机制，典型 POPs
的免疫毒性研究进展
This chapter summarizes the definition and development of
immunotoxicology, the evaluation and mechanism of immunotoxicity, and the
research progress of immunotoxicity of Typical POPs
Section 12
基于课程主题“POPs 免疫毒性”的小组汇报讨论
Group report and discussion based on the subject of the immunotoxicity of
POPs
学生关于“POPs 的免疫毒性”进行案例讨论
An independent case discussion on "the immunotoxicity of POPs" between
students
Section 13
POPs 的内分泌干扰效应
Endocrine disrupting effects of POPs
概述内分泌系统，内分泌干扰效应的作用机制，POPs 的内分泌效应
This chapter summarizes the endocrine system, the mechanism of endocrine
interference effect and the endocrine effect of POPs
Section 14
基于课程主题“POPs 内分泌干扰效应”的小组汇报讨论
Group report and discussion based on the subject of the endocrine disrupting
effects of POPs
学生关于“POPs 的内分泌干扰效应”进行案例讨论
An independent case discussion on "the endocrine disrupting effects of POPs
" between students
Section 15
免疫-神经-内分泌交互作用
Immune neuroendocrine interaction
概述神经系统与免疫系统的相互作用，内分泌系统与免疫系统的相互作
用，神经系统与内分泌系统的相互作用
This chapter summarizes the interaction between nervous system and immune
system, the interaction between endocrine system and immune system, and the
interaction between nervous system and endocrine system
Section 16
高通量测试技术与有害结局路径
High throughput testing technology and harmful outcome path
概述高通量测试技术，有害结局路径的构建，集成测试技术
This chapter summarizes high-throughput testing technology, the construction
of harmful outcome path, and integrated testing technology
13.
课程考核
Course Assessment
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分
比
% of final
score
违纪处罚
Penalty
备注
Notes
√
出勤 Attendance
每周 Every Week
10%
√
课堂表现
Class
Performance
每周 Every Week
40%
小测验
Quiz
课程项目
Projects
√
平时作业
Assignments
16 周
Week 16
20%
期中考试
Mid-Term Test
期末考试
Final Exam
√
期末报告
Final
Presentation
16 周
Week 16
30%
其它（可根据需
要改写以上评估
方式）
Others (The
above may be
modified as
necessary)
14.
教材及其它参考资料
Textbook and Supplementary Readings
教材 Textbook
[1]《持久性有机污染物的生态毒理学》，尹大强，科学出版社，2019
《Environmental Health Effects of Persistent Organic Pollutants》, Yin, D.Q, Science Publishing House,
2019
参考资料 Supplementary Readings
[2]《持久性有机污染物的分析方法和检测技术》，张庆华，科学出版社，2021
《Analytical Methods and Detection Techniques of Persistent Organic Pollutants》, Zhang, Q.H, Science
Publishing House, 2021
[3]《持久性有机污染物内分泌干扰效应》，周炳升，科学出版社，2018
《Endocrine Disrupting Effects Of Persistent Organic Pollutants》, Zhou, B.S, Science Publishing House,
2018
[4] 《Persistent Organic Pollutants》, Lynch, Kaleb, Larsen and Keller Education, 2017