课程大纲
COURSE SYLLABUS
1.
课程代码/名称
Course Code/Title
细胞和组织工程／Cells and Tissue Engineering
2.
课程性质
Compulsory/Elective
选修／Elective
3.
课程学分/学时
Course Credit/Hours
3 学分／48 学时 3 credits/ 48 hours
4.
授课语言
Teaching Language
中英文 Chinese/English
5.
授课教师 Instructor(s)
郭琼玉／Qiongyu Guo
6.
先修要求
Pre-requisites
无／Not applicable
7.
教学目标 Course Objectives
This course aims to develop an in-depth understanding of tissue engineering as a treatment concept to replace and
recover the anatomic structure and functions of the defected, damaged, injured, or missing tissue and organs.
Upon successful completion of this course, students will be able to demonstrate understanding of fundamentals of
cells and tissue development, biologic and molecular basis for tissue engineering, biomaterials for regenerative
medicine, as well as biotechnologies and therapeutic applications.
8.
教学方法 Teaching Methods
Teaching material will be gathered from textbooks and scientific journal articles.
Group discussions will be used to critically analyze scientific results and engineering designs.
Each student will write a proposal of a topic related to the course, and give a presentation to the class.
9.
教学内容 Course Contents
Section 1
Introduction: Describe the main objectives of the course
Section 2
Biology of regeneration: Regeneration at molecular, cell, and tissue levels
Section 3
Fundamentals of tissue development: epithelium, connective tissue, muscle tissue and
nerve tissue
Section 4
Cell therapy: Cell sources, isolation, preservation, proliferation and migration
Section 5
Stem cell therapy: Stemness, plasticity, modification and therapeutic potentials
Section 6
Extracellular matrix: Structural protein, specialized protein and proteoglycan
Section 7
Biological factors: Growth factors, cytokines, chemokines and hormones
Section 8
Scaffolding: Structure, guidance cues, surface chemistry and biocompatibility
Section 9
Transport: Mass transport and vascularization in tissue function
Section 10
Proposal writing: Specific aims, background, significance, preliminary data and
experimental design
Section 11
Polymeric biomaterials: Polymer composition, chemistry and functionality
Section 12
Review: Provide case studies and future challenges
10.
课程考核 Course Assessment
30% 平时作业
30% 课程报告
40% 期末报告
11.
教材及其它参考资料 Textbook and Supplementary Readings
Anwarul Hasan, “Tissue Engineering for Artificial Organs: Regenerative Medicine, Smart Diagnostics and
Personalized Medicine”, Wiley-VCH, 2017, Online ISBN:9783527689934.
Anthony Atala et al, “Principles of Regenerative Medicine, 3rd Edition”, Elsevier, 2018, eBook ISBN:
9780128098936.
