1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问，请
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
寻找生命的逻辑 Genome, why we are different?
2.
授课院系
Originating Department
生物系
3.
课程编号
Course Code
BIOS201
4.
课程学分 Credit Value
2
5.
课程类别
Course Type
专业选修课 Major Elective Courses
6.
授课学期
Semester
夏季 Summer
7.
授课语言
Teaching Language
中英文 Chinese and English
8.
授课教师、所属学系、联系方
式（如属团队授课，请列明其
他授课教师）
Instructor(s), Affiliation&
Contact
（For team teaching, please list
all instructors）
课程负责人：陈炜，生物系，讲席教授，chenw@sustech.edu.cn
工程师：余春红，生物系，高级实验师，yuch@sustech.edu.cn
吕沫，生物系，高级实验师，lvm3@sustech.edu.cn
Course Coordinator:
CHEN Wei, Department of Biology, Chair Professor, chenw@sustech.edu.cn
Instructor:
YU Chunhong, Department of Biology, Senior Experimenter,
yuch@sustech.edu.cn
LV Mo, Department of Biology, Senior Experimenter,
lvm3@sustech.edu.cn
9.
实验员/助教、所属学系、联系
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(可不填)
Maximum Enrolment
（Optional）
无 None
2
11.
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
Other（Pleasespecify）
总学时
Total
学时数
Credit Hours
64
64
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
无 None
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
无 None
14.
其它要求修读本课程的学系
Cross-listing Dept.
无 None
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
在传统的分子生物学实验与生物信息学之间，基因组序列信息的获取以及基因测序仪是最为重要的纽带和桥梁。本课程以
培养学生的科研素养为主，学生将在独特的应用场景下从生物学、基因组学、生物信息学等不同角度来探究到底什么是基
金，基因与人类健康的关系，自主设计科研项目，最终通过动手实验揭秘人的特征性状与基因的关系。课程设置“应用场
景介绍”、“自主设计科研项目”“湿实验”、“干实验”、“ 科学实践”五个单元，让学生能够深入浅出地了解基因组
学与基因技术的前沿知识，完成分子生物学实验与生物信息分析。
In the traditional molecular biology experiment and bioinformatics, the acquisition of genome sequence information and
gene sequencing instrument is the most important link and bridge. This course focuses on cultivating students' scientific
research literacy. Students will explore what is a foundation in a unique application scenario from different perspectives
such as biology, genomics and bioinformatics, and the relationship between genes and human health. They will design
scientific research projects independently, and finally reveal the relationship between human characteristics and genes
through hands-on experiments. The course consists of five units: "Introduction to Application Scenes", "Independent
Design Scientific Research Project", "Wet Experiment", "Dry Experiment" and "Scientific Practice". Students can
understand the cutting-edge knowledge of genomics and gene technology in a simple way, and complete molecular
biology experiments and bioinformatics analysis.
16.
预达学习成果 Learning Outcomes
掌握基因组学与生物信息学的基本原理。
了解高通量测序数据的基本处理方法，完成从变异数据到性状预测的简单计算。
了解基因科技在司法物证、运动指导、精准营养等方面的应用。
深入华大基因与国家基因库，了解基因科技在真实产业场景中的应用。
掌握样本处理、核酸提取、文库构建、基因测序等湿实验技术流程。
完成科研项目，汇报成果。
Master the basic principles of genomics and bioinformatics.
Understand the basic processing methods of high-throughput sequencing data, and complete the simple calculation
from variation data to trait prediction.
To understand the application of gene technology in judicial material evidence, exercise guidance, precision nutrition
and other aspects.
Go deep into BGI and the National Gene Bank to understand the application of gene technology in real industrial
scenarios.
Master wet experimental technical processes such as sample processing, nucleic acid extraction, library construction
and gene sequencing.
3
Complete scientific research projects and report the results.
17.
课程内容及教学日历 （如授课语言以英文为主，则课程内容介绍可以用英文；如团队教学或模块教学，教学日历须注明
主讲人）
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
模块一，什么是基因，基因与人类健康的关系？（应用场景介绍）
1 基因与基因测序技术 1 学时
1.1 基因测序仪——观察基因的“显微镜”
1.2 人类基因组计划
1.3 如何研究人的遗传和基因信息
1.4 本学期研究内容介绍：基因型与表型
Module 1: What are genes and how do they relate to human health? (Introduction to application scenarios)
1 Gene and gene sequencing technology, 1 hour
1.1 Gene Sequencer -- a "microscope" for observing genes
1.2 Human Genome Project
1.3 How to study human heredity and genetic information
1.4 Introduction to the research content of this semester: genotype and phenotype
2 基因与运动 0.5 学时
2.1 不可思议的难题：如何分辨运动员性别
2.2 先天决定？肌肉耐力与爆发力
2 Genes and exercise, 0.5 hour
2.1 The Incredible Problem: How to Distinguish Athletes' Gender
2.2 A priori decision? Muscle endurance and explosive power
3 基因与饮食 0.5 学时
3.1 基因与酒量
3.2 什么基因导致有人喝奶拉肚子？
3. Genes and diet, 0.5 hour
3.1 Genes and alcohol consumption
3.2 What genes cause diarrhea when people drink milk?
4 认识基因实验室 2 学时
4.1 实验室介绍：移液器、PCR 仪、离心机、涡旋震荡仪、电子天平、测序仪等
4.2 移液工具的发展历史
4.3 仪器的使用：移液器、PCR 仪、离心机、涡旋震荡仪、电子天平、测序仪等
4 Cognition gene laboratory, 2 hours
4.1 Laboratory introduction: pipette, PCR instrument, centrifuge, scroll oscillation instrument, electronic balance,
sequencing instrument, etc
4.2 Development history of pipetting tools
4.3 Application of instruments: pipette, PCR instrument, centrifuge, scroll oscillator, electronic balance, sequencing
instrument, etc
5 法医探案实录 1 学时