课程大纲
COURSE SYLLABUS
1.
课程代码/名称
Course Code/Title
植物分子生物学和基因组学前沿
Advanced Studies in Plant Molecular Biology and Genomics
2.
课程性质
Compulsory/Elective
选修课 Elective
3.
课程学分/学时
Course Credit/Hours
2 学分 2 points/32 hours
4.
授课语言
Teaching Language
中英文 Chinese and English
5.
授课教师 Instructor(s)
翟继先
Jixian Zhai
6.
先修要求
Pre-requisites
《普通生物学》 General Biology
7.
教学目标 Course Objectives
Plant Molecular Biology and Genomics is a course is about genes - their structure and function- at the molecular
level. The
objective is to give you a firm and rigorous foundation in understanding gene expression and its
regulation. We will begin with a review of structure of protein and nucleic acid, and the physical and chemical
properties that drive interactions of protein
with nucleic acid. Then we will study methods and technologies
applied to study genes. Next, we will study the molecular mechanics of DNA replication, DNA damage repair,
transcription in both prokaryotic and eukaryotic organisms, with an emphasis on how
the activity of genes is
regulated at the molecular level through nucleic acid-
protein interactions. Lastly, genomics and systems biology
will also be introduced and we will review advances in genomics projects that are altering our understanding of
molecular biology.
8.
教学方法 Teaching Methods
1. Lectures by Professor
2. Group Discussion
The teacher instructs students to give their own opinions about the issue, and make them to communicate and
learn. Through discussion, students will help each other and learn from each other,
deepen their knowledge,
understanding and gain more new knowledge. Besides, their autonomy will also be encouraged in order to solve
problems together.
9.
教学内容 Course Contents
Section 1
i. Course Introduction
ii. A brief history
iii. Hot topics in molecular biology
iv. Protein structure
v. DNA structure and topology
vi. Chromosome structure and its effects on DNA metabolism
vii.
Protein-DNA interaction
Section 2
i. Cloning
ii. Working with genes
iii. Understanding the function of genes
iv. DNA Replication
Section 3
i. DNA mutation and repair
ii. Recombinational DNA Repair and Homologous Recombination
iii. Site-specific recombination and transposition
iv.
Tools for genome editing
v. DNA-dependent RNA synthesis
vi. mRNA processing
vii. mRNA transport
Section 4
i. The genetic code
ii. Protein synthesis
iii. Regulation the flow of information
iv. The transcriptional regulation of gene expression in eukaryotic organisms
v. The posttranslational regulation of gene expression in eukaryotic organisms
vi. Gene Regulation in Development and Evolution
Section 5
Genomes, Transcriptomes, Proteomics, and systems biology
Section 6
The future of molecular biology and Genomics
10.
课程考核 Course Assessment
Attendance (10 points), Presentation (60 points), Report (30 points),
11.
教材及其它参考资料 Textbook and Supplementary Readings
Online text book – Arabidopsis Book, free download.
