课程大纲
COURSE SYLLABUS
1.
课程代码/名称
Course Code/Title
BIO5030/再生生物学与再生医学
BIO5030/ Regenerative Biology and Medicine
2.
课程性质
Compulsory/Elective
选修
Elective
3.
课程学分/学时
Course Credit/Hours
3 学分/48 学时
3 Credits/48 Hours
4.
授课语言
Teaching Language
英语
English
5.
授课教师
Instructor(s)
陈永龙
CHEN, YONGLONG
6.
先修要求
Pre-requisites
细胞生物学
Cell Biology
7.
教学目标
Course Objectives
Regenerative biology refers to the general understanding
of renewal, restoration, and growth that
makes genomes, cells, organisms, and ecosystems resilient to natural fluctuations and disturbance, while
regenerative medicine is a branch of translational research in tissue engineering and molecular b
iology which
deals with the process of replacing, engineering, or regenerating human cells, tissues, or
organs to restore or
establish normal function, such as replacing bone marrow in leukemia, cartilage in osteoarthritis,
or cells of
the heart after a heart attack. Tissue is normally generate
d during fetal development by the differentiation of
embryonic stem cells or during postnatal life by a similar differentiation of adult stem cells. Regenerative
medicine tries to mimic these processes, thus treating patients suffering from degenerative diseases.
In this course, we will 1) discuss the achievements
of stem cell research on both pluripotent stem cells
and adult stem cells, and challenges lying ahead, including bioethical issues; 2)
explore basic mechanisms of
how cells differentiate into various tissues in response to a variety of biologic signalling molecules
, as well
as application of such factors for in vitro tissue engineering; and 3) discuss the recent advancement on
clinical
trials dealing with various degenerative diseases.
8.
教学方法
Teaching Methods
This course will be conducted with lectures (24 hrs) in combination with student paper
presentations/journal clubs (24 hrs). Every student needs to write two commentary/review essay
s (each essay
with no less than 300 words) on journal club topics.
课堂讲授时注意引导学生就再生生物学和再生医学的重要现象展开讨论，从中发掘归纳出科学
问题，并寻找相应的解决问题的思路和方法，比较在不同实验技术背景下研究思路的差异。鼓励学
生积极提出自己的想法，不要轻易接受一种现成的理论。学生们将选择经典的科学问题，就最新进
展做口头报告，并以短文形式陈述自己的独到见解。
9.
教学内容
Course Contents
Section 1
Introduction of regenerative biology
Section 2
Introduction of regenerative medicine, using pancreas development, pancreatic
beta cell regeneration, and cell transplantation therapy of diabetes as an
example.
Section 3
Embryonic stem cells and nuclear transplant cloning
Section 4
Induced pluripotent stem cells
Section 5
Gastruloids
Section 6
Adult stem cells and organoids
Section 7
Regenerative biology of peripheral nervous system
Section 8
Regenerative medicine of peripheral nervous system
Section 9
Regenerative biology and medicine of eyes
Section 10
Regenerative biology of central nervous system
Section 11
Regenerative medicine of central nervous system
Section 12
Regenerative biology of skin
Section 13
Regenerative medicine of skin
Section 14
Tissue engineering of the reproductive system
Section 15
Regenerative biology and medicine of heart
Section 16
Regenerative biology and medicine of blood
Section 17
Regenerative biology of hepatocytes
Section 18
Regenerative medicine of liver
Section 19
Intestine stem cells
Section 20
Regenerative medicine of intestine
Section 21
Regenerative biology of lung
Section 22
Regenerative medicine of lung
Section 23
Regenerative biology and medicine of limb
Section 24
Review
10.
课程考核
Course Assessment
请再此注明：
①考试；
②分数构成:
1. Class participation 20%
2. Presentations 25%
3. Commentary Essays 25%
3. Final Exam 30%
11.
教材及其它参考资料
Textbook and Supplementary Readings
Reference books:
• Regenerative Biology and Medicine, 2
nd
, David L. Stocum. 2012
• Regenerative Medicine and Tissue Engineering. Editor Jose A. Andrades, ISBN 978-953-51-1108-5.
2013
