1
课程大纲
COURSE SYLLABUS
1.
课程代码
/
名称
Course Code /Title
BIO5012 生物信息学
Bioinformatics
2.
课程性质
Compulsory/Elective
Elective (选修)
3.
课程学分/学时
Course Credits/Hours
2/32
4.
授课语言
Teaching Language
English
5.
授课教师
Instructor(s)
Andrew Hutchins
6.
先修要求
Pre-requisites
None
7.
教学目标 Course Objectives
Bioinformatics is a practical, hands-on approach to the field of computational biology. The course is
recommended for biologists who are interested in getting a grounding in the application of
computational techniques to biology.
This
course will have a particular emphasis on next generation sequencing techniques, which are
rapidly becoming all-pervasive in biological studies.
There will be practical assignments utilizing the tools described.
8.
教学方法
Teaching Methods
A combination of lectures and hands-on activities.
9.
教学内容
Course Contents
Section 1
Introduction, bioinformatics, systems biology, genomes, and the Human genome project
Section 2
Internet and online database resources (Assignment 1)
Section 3
Protein domains and nucleic acid sequence and sequence alignment, phylogeny and clustering
(Assignment 2)
Section 4
Bioinformatics and the laboratory (Assignment 3)
2
Section 5
Genomes, consortiums and sequence databases (Assignment 4)
Section 6
Gene expression, Microarrays, RNA-seq, ChIP-seq, sequencing
Section 7
GALAXY and IGV
Section 8
Gene ontology and molecular pathways (DAVID, GREAT)
Section 9
Regulatory genomics, transcription factors and motif discovery
Section 10
The (Advanced) bioinformaticians toolkit
Section 11
Network biology
Section 12 Structural Biology
Section 13 Computational modeling of biological phenomena
Section 14 Presentation 1
Section 15 Presentation 2
Section 16 The dark matter of the genome, an appreciation for repetitive genomic elements
Section 17 Evodevo genomics
10.
课程考核
Course Assessment
Students are required to finish a final project along with coursework
11.
教材及其它参考资料
Textbook and Supplementary Readings
• Agostino M, Practical Bioinformatics, Garland Science.
