1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问，请
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
免疫学 Immunology
2.
授课院系
Originating Department
生物系 Department of Biology
3.
课程编号
Course Code
BIO405
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业选修课 Major Elective Courses
6.
授课学期
Semester
春季 Spring / 夏季 Summer / 秋季 Fall
7.
授课语言
Teaching Language
专业选修课 （生物科学、生物技术、生物信息学专业）
Major Elective Courses(Biological Sciences, Biotechnology，Bioinformatics Majors)
8.
授课教师、所属学系、联系方
式（如属团队授课，请列明其
他授课教师）
Instructor(s), Affiliation&
Contact
（For team teaching, please list
all instructors）
侯春晖，生物系；第一科研楼 308；hou.ch@sustc.edu.cn
HOU Chunhui, Department of Biology;Rm 308, 1st Research Bldg.
9.
实验员/助教、所属学系、联系
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(可不填)
Maximum Enrolment
（Optional）
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
Other（Please specify）
总学时
Total
11.
学时数
Credit Hours
2 期中考试 Midterm exam
48
2
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
BIO206-15 细胞生物学
Cell Biology
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
本课程为生物学专业选修课，是从事生物学研究的重要基础课程；其他非生物学专业学生
也可选修本课程，对免疫和人类健康有所了解。
This course shall be taken by those majoring in biology and plan to do basic or clinical
research in the future. It is also suitable for non-specialists to understand how immune
system to work to protect human from the attack of various pathogens.
14.
其它要求修读本课程的学系
Cross-listing Dept.
None 无
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
为本科生介绍基本的免疫学概念，免疫反应机理，免疫失调和疾病治疗。
To introduce basic immunology concepts suitable for students at undergraduate level.
16.
预达学习成果 Learning Outcomes
通过学习本课程，学生将能掌握免疫学的基本概念，理解免疫反应的过程，认识免疫学方面的问题并为将来的学习工作打
下基础。
The overall learning goals for the course are: 1) to master the fundamental concepts of immunology; 2) to understand
the process of immune responses; and 3) to develop interest in addressing elusive immunological questions.
17.
课程内容及教学日历 （如授课语言以英文为主，则课程内容介绍可以用英文；如团队教学或模块教学，教学日历须注明
主讲人）
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
1．General Introduction (2 hours)
A historical perspective of Immunology
Important concepts for understanding the mammalian immune response
The good, bad and ugly of the immune system
2．Immune System (2 hours)
Cells of the immune system
Primary lymphoid organs-where immune cells develop
Secondary lymphoid organs-where the immune response is initiated
3．B-Cell Receptors & T-Cell Receptors (4 hours)
Receptor-ligand interactions
Common strategies used in many signaling pathways
Frequently encountered signaling pathways
The structure of antibodies
3
Signal transduction in B cells
T-Cell receptors and signaling
4．Cytokines and Chemokines (4 hours)
General properties of cytokines and chemokines
Six families of cytokines and associated receptor molecules
Cytokine antagonists
Cytokine-related diseases
Cytokine-based therapies
5．Innate Immunity (2 hours)
Anatomical barriers to infection
Phagocytosis
Induced cellular innate responses
Inflammatory responses
Natural killer cells
Regulation and evasion of innate and inflammatory responses
Interactions between the innate and adaptive immune systems
Ubiquity of innate immunity
6．Complement System (2 hours)
The major pathways of complement activation
The diverse functions of complement
The regulation of complement activity
Complement deficiencies
Microbial complement evasion strategies
The evolutionary origins of the complement system
7．Lymphocyte Receptor Genes (2 hours)
The puzzle of immunoglobulin gene structure
Multigene organization of Ig genes
The mechanism of V(D)J recombination
4
B-cell receptor expression
T-cell receptor genes and expression
8．MHC and Antigen Presentation (4 hours)
The structure and function of MHC molecules
General organization and inheritance of the MHC
The role of the MHC and expression patterns
The endogenous pathway of antigen processing and presentation
The exogenous pathway of antigen processing and presentation
Cross-presentation of exogenous antigens
Presentation on nonpeptide antigens
9．T- and B-Cell Development (3 hours)
Early thymocyte development
Positive and negative selection
Lineage commitment
Exit from the thymus and final maturation
Other mechanisms that maintain self-tolerance
Apoptosis
The site of hematopoiesis
B-cell development in the bone marrow
The development of B-1 and marginal-zone B cells
Comparison of B- and T-cell development
10．T- and B-Cell Activation, Differentiation and Memory (3 hours)
T-cell activation and the two signal hypothesis
T-cell differentiation
T-cell memory
T-dependent B-cell responses
T-independent B cell responses
Negative regulation of B cells
5
11．Immune Response (4 hours)
Antibody-mediated effector functions
Cell-mediated effector responses
Experimental assessment of cell-mediated cytotoxicity
Immune cell behavior before antigen is introduced
Immune cell behavior during the innate immune response
Immune cell behavior during the adaptive immune response
Immune cell behavior in peripheral tissues
12．Allergies, Hypersensitivities and Chronic Inflammation (2 hours)
Allergy: A Type I hypersensitivity reaction
Antibody-mediated (Type II) hypersensitivity reactions
Immune complex-mediated (Type III) hypersensitivity
Delayed-type (Type IV) hypersensitivity (DTH)
Chronic inflammation
13．Tolerance, Autoimmunity and Transplantation (2 hours)
Establishment and maintenance of tolerance
Autoimmunity
Transplantation immunology
14．Infectious Diseases and Vaccines (4 hours)
The importance of barriers to infection and the innate response
Viral infections
Bacterial infections
Parasitic infections
Fungal infections
Emerging and re-emerging infectious diseases
Vaccines
15．Immunodeficiency (2 hours)
Primary immunodeficiency
6
Secondary immunodeficiency
16．Cancer and the Immune System (2 hours)
Terminology and common types of cancer
Malignant transformation of cells
Tumor antigens
The immune response to cancer
Cancer immunotherapy
17．Experimental Systems and Methods (2 hours)
Antibody generation
Immunoprecipitation-based techniques
Microscopic visualization of cells and subcellular structures
Flow cytometry
Cell cycle analysis
Whole animal experimental systems
2 hours for Mid-term examination.
18.
教材及其它参考资料 Textbook and Supplementary Readings
Required: Owen, Punt and Stranford, Kuby Immunology, 7th Edition.
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
出勤 Attendance
20
课堂表现
Class
Performance
小测验
Quiz
课程项目 Projects
平时作业
Assignments
期中考试
Mid-Term Test
40
期末考试
Final Exam
40
期末报告
Final
Presentation
其它（可根据需要
7
改写以上评估方
式）
Others (The
above may be
modified as
necessary)
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制（通过/不通过） Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/委员会审议通过
This Course has been approved by the following person or committee of authority
本课程经生物系本科教学指导委员会审议通过。
This Course has been approved by Undergraduate Teaching Steering Committee of Department of Biology.