1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问，请
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
高级细胞生物学 Advanced Cell Biology
2.
授课院系
Originating Department
生物系
Department of Biology
3.
课程编号
Course Code
BIO323
4.
课程学分 Credit Value
2
5.
课程类别
Course Type
专业选修课(生物科学、生物技术、生物信息学）
Major Elective Courses (Biological Sciences, Biotechnology, Bioinformatics)
6.
授课学期
Semester
春季 Spring
7.
授课语言
Teaching Language
英文 English
8.
授课教师、所属学系、联系方
式（如属团队授课，请列明其
他授课教师）
Instructor(s), Affiliation&
Contact
（For team teaching, please list
all instructors）
张严冬，助理教授，生物系
第 1 科研楼 335 室
zhangyd@sustc.edu.cn
0755-8801-8422
ZHANG, Yandong , Assistant Professor, Department of Biology
Rm.335, No.1 Research Bldg.
9.
实验员/助教、所属学系、联系
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(可不填)
Maximum Enrolment
（Optional）
20
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
Other（Please specify）
总学时
Total
11.
学时数
Credit Hours
0
0
0
32
2
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
BIO206-15 细胞生物学
Cell Biology
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
本课程为生物系专业选修课，对有兴趣了解并扩展细胞生物专业领域的学生比较适合。
This course should be taken by students who intend to expand their knowledge and
understanding about cell biology
14.
其它要求修读本课程的学系
Cross-listing Dept.
无 None
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
这门课简介人类细胞在病理条件下的反应和一些致病机理。我们把课程分为几个主要的模块，包括病原微生物对人类宿主
细胞的侵袭和细胞的反应，这一过程的失调所导致的人类疾病过程；人免疫系统对外界病原的反应机理；多细胞生物的发
育过程中的重要信号转导机制及失调导致的人类疾病；非编码 RNA 及其对基因的调控；细胞的迁移和癌症转移的分子机
理；细胞的重编程和诱导多功能干细胞等题目。学生在每个模块学习之后需要参与小组讨论并学习简介一篇相关文献。
This course focuses on cell biology in pathology. We choose topics that are currently in the frontiers in cell biology and
their deregulation is linked to human diseases. The topics include bacterial and virus pathogenesis, immune response;
cellular signaling during development as well as its dysregulation in cancer; Non-coding RNA and gene regulation; cell
migration and cancer metastasis; cell programming and pluripotent stem cells. Students are required to participate in
group discussion and should give one research article presentation based on his interest.
16.
预达学习成果 Learning Outcomes
学生对细胞在病理条件下的异常反应会有更深入的了解， 同时涉及的课题将是最前沿的研究领域。 Students are
expected to have a deeper understanding about patholody, the topics covered in the lectures will be cutting-edge
research.
17.
课程内容及教学日历 （如授课语言以英文为主，则课程内容介绍可以用英文；如团队教学或模块教学，教学日历须注明
主讲人）
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
Week No.
讲座题目 Lecture Topic
学时 hours
讲座具体内容
Lecture Contents
Week 1
模块 1：病原侵染的细胞生物学
Module I: Cell Biology of
infection
2 学时
2 hours
病原微生物的种类
病原微生物的典型生活周期
病原进入宿主的途径机理
病原微生物的致病机理
Category of pathogens
Life cycles of pathogens
Entry routes of pathogens
Virulence factors and mechanisms
Week 2
模块 1： 免疫应答和信号通路
Module I: Immune response and
2 学时
2 hours
爱德华医生和天花疫苗
人类细胞的防御系统
3
the signaling pathway
病原微生物和先天免疫
病毒和干扰素
后天免疫系统简介
Edward Jenner and small pox
Defence systems in human being
Pathogens and innate immunity
Virus and interferons
Adaptive immune system
Week 3
模块 1： 免疫和癌症治疗 Module I:
Immunology and Cancer prevention
2 学时
2 hours
B 细胞系统应答
T 细胞系统应答
抗体的多样化机理
免疫治疗
cell response
T cell response
Diversification of antibodies
immunotherapy
Week 4
小组讨论和学生报告
Group discussion and
presentation
2 学时
2 hours
Week 5
模块 2： 发育和信号转导通路
Module II: 1. Development and
signaling pathways
2 学时
2 hours
人体发育和出生缺陷
发育的基本步骤
发育中的关键基因的发现
Human development and birth defects
Key steps in development
Critical genes in development
Week 6
模块 2：发育和信号通路 Module II:
2. Development and signaling
pathways
2 学时
2 hours
Notch 信号通路
Wnt 信号通路
Hedgehog 信号通路
Hippo 信号通路
4
Notch signaling
Wnt signaling
Hedgehog signaling
Hippo signaling
Week 7
模块 2： 发育失调和人类疾病
Module II: Development and its
dysregulation
2 学时
2 hours
Par 基因和细胞的不对称分裂
果蝇中的花样形成机理
发育中的细胞迁移 和原肠胚
Par gene and asymmetric division
In C. elegans development
Pattern formation in drosophila
And its underlying mechanisms
Gastrulation and molecular control
Week 8
小组讨论和学生报告
Group discussion and
presentation
2 学时
2 hours
Week 9
模块 3：细胞迁移和癌症转移 Module
III: Cell migration and cancer
metastasis
2 学时
2 hours
癌症转移的“种子土壤”理论
的提出
肿瘤迁移的具体步骤
EMT 理论的提出
肿瘤迁移中的重要调控因子
和其失调
The “ seed and soil” theory
Detailed steps in metastasis
EMT theory
Cricital factors in metastasis
Week 10
小组讨论和学生报告
Group discussion and
presentation
2 学时
2 hours
Week 11
期中考试
Midterm exam
2 学时
2 hours
5
Week 12
模块 4：非编码 RNA 及其对基因的调
控 Module IV. Non-coding RNA
control of gene expression,
2 学时
2 hours
siRNA and micro RNA
linc RNA
circular RNA
piRNA, etc
Week 13
小组讨论和学生报告
Group discussion and
presentation
2 学时
2 hours
Week 14
模块 5： 细胞重编程和诱导多功能干
细胞 Module V. Cell reprogramming
Pluripotent stem cells
2 学时
2 hours
Yamanaka 因子
诱导多功能干细胞的方法
分化细胞之间的转化
多功能干细胞的应用
Yamanaka factors
Induced iPS
Conversion of differentiated cells
Applications of iPS
Week 15
小组讨论和学生报告
Group discussion and
presentation
2 学时
2 hours
Week 16
复习
Review session
2 学时
2 hours
Final weeks
Final Exam
18.
教材及其它参考资料 Textbook and Supplementary Readings
无 none
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
6
出勤 Attendance
课堂表现
Class
Performance
小测验
Quiz
课程项目 Projects
40
平时作业
Assignments
期中考试
Mid-Term Test
30
期末考试
Final Exam
30
期末报告
Final
Presentation
其它（可根据需要
改写以上评估方
式）
Others (The
above may be
modified as
necessary)
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制（通过/不通过） Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/委员会审议通过
This Course has been approved by the following person or committee of authority
本课程经生物系本科教学指导委员会审议通过。
This Course has been approved by Undergraduate Teaching Steering Committee of Department of Biology.