1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问，请
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
神经生物学 Neurobiology
2.
授课院系
Originating Department
生物系 Department of Biology
3.
课程编号
Course Code
BIO310
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业选修课（生物科学、生物技术、生物信息学专业）
Major Elective Courses（Biological Sciences, Biotechnology, Bioinformatics Majors）
6.
授课学期
Semester
春季 Spring / 秋季 Fall
7.
授课语言
Teaching Language
英文 English
8.
授课教师、所属学系、联系方
式（如属团队授课，请列明其
他授课教师）
Instructor(s), Affiliation&
Contact
（For team teaching, please list
all instructors）
姬生健，生物系 JI Shengjian, Biology Department
jisj@sustech.edu.cn，88018498
程龙珍，生物系 CHENG Longzhen, Biology Department
chenglz@sustech.edu.cn
9.
实验员/助教、所属学系、联系
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(可不填)
Maximum Enrolment
（Optional）
50
授课方式
Delivery Method
讲授
Lectures
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
Other（Please specify）
总学时
Total
11.
学时数
Credit Hours
40
8 （神经生物学最新文献阅
读 、 讲 解 和 讨 论
Neuroscience article
reading, presentation and
discussion）
48
2
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
生物化学 I（BIO201）
Biochemistry(Macromolecules)
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
None 无
14.
其它要求修读本课程的学系
Cross-listing Dept.
None 无
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
神经生物学是为中高年级的本科生和一年级的研究生开设的生物学课程。本课程的总体目标是帮助学生了解控制神经系统
结构、组织、发育、功能和疾病的基本原理。
Neurobiology is an advanced biology course designed for junior/senior undergraduate students and first-year graduate
students. The overall goal of this course is to provide students a starting point to understand the fundamental principles
governing the structure, organization, development, function and diseases of nervous system.
16.
预达学习成果 Learning Outcomes
理解和掌握现代神经生物学的基本知识、研究方法和思维方法。
Learn the basic principles, methods and ideas for modern neuroscience.
提高学生在神经科学领域的报告和交流能力。
Improve the skills for scientific presentation and communication in neuroscience.
17.
课程内容及教学日历 （如授课语言以英文为主，则课程内容介绍可以用英文；如团队教学或模块教学，教学日历须注明
主讲人）
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
Part 1, Introduction & Structure and Organization of Nervous System (2 h)
Outline: model organisms in neuroscience; cellular components of nervous system; neurons; glia; organization of
nervous system; survey of human neuroanatomy.
Part 2, Nervous System Development and Diseases (10 h)
Section 2.1. Early nervous system development
Outline: formation of nervous system; neural stem cells; neural crest; segmentation and Hox genes; molecular basis of
neural induction; major inductive signaling pathways in vertebrate embryos (RA, FGF, BMP, Wnt; Shh);
neurogenesis; molecular and genetic disruptions of early neural development; neural migration.
Section 2.2. Construction of neural circuits
Outline: cell polarity; axon growth and guidance; actin and tubulin; signals for axon guidance; chemoattraction and
chemorepulsion; synapse formation; neurotrophic interactions; synaptic refinement; neurotrophins.
Section 2.3. Modification of neural circuits as a result of experience
Outline: critical period; critical periods in visual system development; critical period for language.
Section 2.4. Repair and regeneration in nervous system
Outline: three types of neural repair; peripheral nerve regeneration; restoration of damaged central nerve cells; adult
neurogenesis (non-mammalian and mammalian).
Part 3, Neural Signaling (14 h)
Section 3.1. Electrical signals of nerve cells
Outline: resting membrane potential; action potential; passive and active current flow in axons; how neuronal electrical
signals arise; electrochemical equilibrium; Nernst equation; Goldman equation; long-distance signaling by means of
action potentials.
Section 3.2. Ion channels and transporters
Outline: patch clamping; ion channels; structure of K
+
channels; active transporters; Na
+
/K
+
pump.
3
Section 3.3. Synaptic transmission
Outline: electrical synapses; chemical synapses; chemical neurotransmission; criteria that define a neurotransmitter; two
types of neurotransmitter; molecular mechanisms of synaptic vehicle cycling; neurotransmitter receptors; end plate
current; end plate potential; reversal potentials; postsynaptic current and potential; excitatory and inhibitory
postsynaptic potentials; summation of synaptic potentials.
Section 3.4. Neurotransmitters and their receptors
Outline: categories of neurotransmitters; acetylcholine and its receptors; glutamate and its receptors (eps. AMPA
receptors); GABA and glycine; biogenic amines (dopamine, histamine, serotonin); peptide neurotransmitters
(substance P, opioid peptides).
Section 3.5. Molecular signaling within neurons
Outline: chemical signaling and different forms; three classes of signaling molecules; receptor types; channel-linked
receptors; enzyme-linked receptors; G-protein-coupled receptors; G-proteins and their molecular targets; second
messengers (Ca
2+
, cyclic nucleotides, diacylglycerol and IP
3
); protein kinases and phosphatases; CREB; c-fos.
Section 3.6. Synaptic plasticity
Outline: short-term synaptic plasticity; long-term synaptic plasticity; synaptic facilitation; synaptic depression; synaptic
potentiation and augmentation; synaptic plasticity in Aplysia; synaptic mechanisms in Aplysia; long-term potentiation
(LTP); long-term depression (LTD); mechanisms underlying LTP and LTD.
Part 4, Sensory System (10 h)
Section 4.1. Somatic sensory system
Outline: sensation and sensory processing; sensory transduction; somatic sensory afferents; two-point discrimination;
mechanoreceptors for proprioception; central pathways conveying tactile information from the body---the dorsal
column-medial lemniscal system; central pathways conveying proprioceptive information from the face; primary
somatic sensory cortex; plasticity in the adult cerebral cortex.
Section 4.2. Pain
Outline: nociceptors; neuronal basis of pain; first and second pain; nociceptive axon subtypes; central pain pathways;
nociceptive and mechanosensory pathways; sensitization; the placebo effect.
Section 4.3. Vision: the eye
Outline: retina; retinal circuitry; structure of retina; rods and cones; retinal pigment epithelium; phototransduction; retinoid
cycle; light adaptation; functional specialization of rod and cone systems; differences in transduction mechanisms of
rod and cone; anatomical distribution of rods and cones; cones and color vision; abnormalities of color vision;
genetics of the cone pigments.
Section 4.4. The chemical senses
Subsection 4.4.1. Olfactory system
Outline: organization of the olfactory system; olfactory perception in humans; olfactory epithelium and olfactory receptor
neurons; odor transduction; odorant receptor proteins; odorant receptor genes; physiological mechanisms of odor
transduction; the olfactory bulb; cortical processing of olfactory information.
Subsection 4.4.2. Taste system
Outline: organization of the taste system; taste perception in humans; taste papillae and taste buds; tastants; peripheral
innervation of the tongue; taste categories; taste receptor proteins and transduction.
Part 5, Brain Imaging Techniques and Complex Brain Functions (4 h)
Section 5.1. Brain imaging techniques
Outline: CT; MRI; functional brain imaging; PET; SPECT; fMRI.
Section 5.2. Association cortex and cognition
Outline: association cortex and cognition; cortical structure; unique features of the association cortices; contralateral
neglect syndrome; cognition study in monkeys; temporal association cortex mediates recognition; frontal association
cortex mediates planning and decision making.
Section 5.3. Sleep and wakefulness
Outline: some facts about sleep; why do humans sleep? circadian cycle of sleep and wakefulness; stages of sleep;
neural circuits governing sleep; sleep disorders.
Part 6, Neuroscience journal club (8 h)
Outline: 1~2 students will be assigned with a most recent or classic scientific article in neuroscience. They will read
carefully and then present this paper to the class.
18.
教材及其它参考资料 Textbook and Supplementary Readings
4
教材 Textbooks:
Neuroscience, 5th ed., Dale Purves et al., Sinauer Associates
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
出勤 Attendance
10
课堂表现
Class
Performance
10
小测验
Quiz
课程项目 Projects
30
Neuroscience article reading,
presentation and discussion
平时作业
Assignments
期中考试
Mid-Term Test
20
期末考试
Final Exam
30
期末报告
Final
Presentation
其它（可根据需要
改写以上评估方
式）
Others (The
above may be
modified as
necessary)
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制（通过/不通过） Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/委员会审议通过
This Course has been approved by the following person or committee of authority
本课程经生物系本科教学指导委员会审议通过。
This Course has been approved by Undergraduate Teaching Steering Committee of Department of Biology.
