Part 1: Single reaction: 8 hours
第一部分:单一反应:8 学时
Outline (Requirement):
主要内容(教学要求):
1.1.Introduction to systems biology; Basic biology crash course;Michaelis-Menten kinetics;Matlab tutorial;
2.1. 系统生物学简介;生物系基本过程的回顾;米氏动力学;Matlab 简要教程
3. 1.1 The fundamental thinking in systems biology: Aristotle’s “four causes”, Sullivan’s rule (familiar with)
4. 1.1 系统生物学的关键思想:亚里士多德的四因论,Sullivan 原则
5. 1.2 Emerging and re-emerging of systems biology: Lac Operon, Phenotype vs function, reverse engineering (familiar
with)
6. 1.2 系统生物学的出现和重新出现:Lac Operon,显性性状与功能
7. 1.3 Major themes in systems biology (understand)
8. 1.3 系统生物学的主要研究方向
9. 1.4 Brief review of central dogma, gene regulations (understand)
10. 1.4 中心法则,基因调控的简要回顾
11. 1.5 Review of Michaelis-Menten kinetics for single reactions: pseudo-steady state approximation (understand)
12. 1.5 回顾单一反应的米氏动力学:准稳态近似
13. 1.6 Tutorial on Matlab (familiar with)
14. 1.6 Matlab 简要教程
15.2. Equilibrium binding, cooperativity and ultrasensitivity:
16.2. 平衡结合,协同效应和超灵敏性
17. 2.1 Dynamic simulation of Michaelis-Menten kinetics (understand)
18. 2.1 米氏动力学的模拟
19. 2.2 Derivation of equilibrium binding (familiar with)
20. 2.2 平衡结合的推导
21. 2.3 Cooperativity and ultrasensitivity: theory, biological examples and functions (familiar with)
22. 2.3 协同效应和超敏感性,理论,生物学例子与功能
23. 2.4 Students share work-in-progress of the first course project