1
课程详述
COURSE SPECIFICATION
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
系统生物学 Systems Biology
2.
授课院系
Originating Department
生物系 Department of Biology
3.
课程编号
Course Code
BIO304
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业核心课 (生物信息专业)
Major Core Courses (Bioinformatics Major)
专业选修课 (生物科学、生物技术专业、生物医学工程专业)
Major Elective Courses (BioscienceBiotechnologyBiomedical Engineering Majors)
6.
授课学期
Semester
春季 Spring / 秋季 Fall
7.
授课语言
Teaching Language
英文 English / 中英双语 English & Chinese
8.
他授课教师)
Instructor(s), Affiliation&
Contact
For team teaching, please list
all instructors
生物系 Department of Biology
Dr. 黄巍 (Huang Wei), huangw@sustc.edu.cn
生物医学工程系 Department of Biomedical Engineering
Dr. 何俊龙(HE Junlonghejl@sustc.edu.cn
9.
/
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(不填)
Maximum Enrolment
Optional
2
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
OtherPlease specify
总学时
Total
11.
学时数
Credit Hours
48
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
Pre-requisites(先BIO102A General Biology MA212
统计 Probability and Statistics
BIO206-15 Cell BiologyDept.BIO
MA206 Mathematical ModelingDept.MATHPHY203-15
学物 Mathematical Methods in Physics系学, Dept.PHYBMEB311
量生理学 I Quantitative Physiology I(生物医学工程系学生,Dept.BMEB))
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
14.
其它要求修读本课程的学系
Cross-listing Dept.
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
系统生物学是一门专业必修课,旨在帮助学生深入理解生物研究中的系统化研究思维、研究课题及方法的科学背景,学习
科学研究的严谨方法,激励其科学好奇心和勇气,并培养学生热爱自然、关爱社会、珍视生命的情操,提高生命科学知识
素养而开设的综合性素质教育必修课程
Systems biology is a subject-foundation course. It is designed to help students understand systematic thinking of
biological researchesscientific backgrounds of research topics andmethodology. It is to train their vigorous research
methods, inspire their scientific curiosity and courage. It is also to help them establish general scientific characters, such
as loving nature, devoting to society, respective to life.
16.
预达学习成果 Learning Outcomes
本课程完成后,学生将能够:
1)培养对生物问题的系统化认知的视角
2)培养对系统生物学一些经典课题的科学背景,生物问题和系统生物学的理论和实验方法的了解。
3)掌握一定的系统生物学数学模拟的能力。
4)培养对生命科学及其交叉学科的兴趣,提高未来与其它学科的人士交流合作的能力。
With the completion of this course, the students will
1develop systematic thinking of biological questions;
2 develop the understanding of the theoretical and experimental approaches for classic systems biology topics,
including backgrounds and biological questions;
3obtain capability of basic systems biology mathematic and computational modelings;
4 develop their interests in biological science and related interdisciplinary sciences, improve their capability of
collaboration with scientists of other disciplines.
17.
课程内容及教学日历 (如授课语言以英文为主,则课程内容介绍可以用英文;如团队教学或模块教学,教学日历须注明
主讲人)
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
3
Part 1: Single reaction: 8 hours
第一部分:单一反应:8 学时
Outline (Requirement)
主要内容(教学要求):
1.1.Introduction to systems biology; Basic biology crash courseMichaelis-Menten kineticsMatlab tutorial;
2.1. 系统生物学简介;生物系基本过程的回顾;米氏动力学;Matlab 简要教程
3. 1.1 The fundamental thinking in systems biology: Aristotle’s “four causes”, Sullivan’s rule (familiar with)
4. 1.1 系统生物学的关键思想:亚里士多德的四因论,Sullivan 原则
5. 1.2 Emerging and re-emerging of systems biology: Lac Operon, Phenotype vs function, reverse engineering (familiar
with)
6. 1.2 系统生物学的出现和重新出现:Lac Operon,显性性状与功能
7. 1.3 Major themes in systems biology (understand)
8. 1.3 系统生物学的主要研究方向
9. 1.4 Brief review of central dogma, gene regulations (understand)
10. 1.4 中心法则,基因调控的简要回顾
11. 1.5 Review of Michaelis-Menten kinetics for single reactions: pseudo-steady state approximation (understand)
12. 1.5 回顾单一反应的米氏动力学:准稳态近似
13. 1.6 Tutorial on Matlab (familiar with)
14. 1.6 Matlab 简要教程
15.2. Equilibrium binding, cooperativity and ultrasensitivity:
16.2. 平衡结合,协同效应和超灵敏性
17. 2.1 Dynamic simulation of Michaelis-Menten kinetics (understand)
18. 2.1 米氏动力学的模拟
19. 2.2 Derivation of equilibrium binding (familiar with)
20. 2.2 平衡结合的推导
21. 2.3 Cooperativity and ultrasensitivity: theory, biological examples and functions (familiar with)
22. 2.3 协同效应和超敏感性,理论,生物学例子与功能
23. 2.4 Students share work-in-progress of the first course project