1
课程详述
COURSE SPECIFICATION
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
生物化学 II(新陈代谢)Biochemistry II (Metabolism)
2.
授课院系
Originating Department
生物系
Department of Biology
3.
课程编号
Course Code
BIO202
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业基础课 Major Foundational Courses
6.
授课学期
Semester
春季 Spring / 秋季 Fall
7.
授课语言
Teaching Language
英文 English / 中英双语 English & Chinese
8.
他授课教师)
Instructor(s), Affiliation&
Contact
For team teaching, please list
all instructors
生物系 Department of Biology
肖国芝,教授,,第一科研楼 341 xiaogz@sustc.edu.cn
王冠宇,副教授,第一科研楼 207 wanggy@sustc.edu.cn
饶枫,副教授,第一教学楼 415 raof@sustc.edu.cn
XIAO Guozhi, Professor, Rm.341, No.1 Research Bldg.
WANG Guanyu, Associate Professor, Rm.207, No.1 Research Bldg.
RAO Feng, Associate Professor, Rm.416, No.1 Teachin Bldgg.
9.
/
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(不填)
Maximum Enrolment
Optional
授课方式
Delivery Method
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
OtherPlease specify
总学时
Total
11.
学时数
Credit Hours
8 (presentation)
48
2
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
BIO201 生物化学 I
Biochemistry (Metabolism)
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
本课程为生物科学、生物信息学和生物技术专业基础课,是绝大部分应用到新陈代谢的
修课程;非生物系学生如果对生物化学和新陈代谢有兴趣,也可选修本课程。
This course should be taken by everyone contemplating doing Biological
Sciences,Bioinformatics or Biotechnology in the following years and it is a prerequisite
for courses that have metabolism as an important component. It should however also be
suitable for non-specialists, i.e. for all those students who are interested in Biochemistry
and Metabolism.
14.
其它要求修读本课程的学系
Cross-listing Dept.
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
本课程旨在确保南科大生物系学生掌握生命的基本过程新陈代谢,亦即生物体从环境摄取营养物转变为自身物质和能
量,同时将自身原有组成转变为废物排出到环境中的不断更新的过程。同时,通过讲解目前用于生物化学领域的研究方
法,结合研究热点,对教材内容进行深入讲解。通过本课程的学习,学生可以掌握合成代谢和分解代谢的基本原理,较为
详细地理解物质和能量在生物体内转化的过程和功用,以及该领域的主要研究方法和思路。希望通过对生物化学 II 的学
习,学生们能更深入地了解生物化学 I 中大分子为何如此构造,实现从分子动力学原理到系统功能的跨越。这样在以后的
研究和工作过程中,学生们可以采用生物化学的研究思路发现和解决问题,并且能够更进一步拓展到其他实际应用中去。
The purpose of this course is to ensure that the students can master the basic process of life-metabolism which means
that organism uptake nutrition as its material and energy, while their original composition secretion is discharged to the
environment. Moreover, I will elucidate the content of the textbook in detail through explaining the current research
methods used in biochemistry and combined with research hotspots. Through this course, students can master the basic
principle of anabolism and catabolism and understanding the process of the material and energy conversion and
functions in living organisms, as well as the main areas of research methods and ideas. It is hoped that through the study
of biochemistry II, students will be able to know more about how the macromolecules are constructed in biochemistry I so
as to achieve the leap from the molecular dynamics principle to the system function. Thus, in the future research and
work process, students can use biochemical research ideas to find and solve problems, and can expand to other
practical applications.
16.
预达学习成果 Learning Outcomes
掌握和分本原反应
换,自由能的计算;掌握糖代谢(包括糖酵解、糖异生、柠檬酸循环、氧化磷酸化、戊糖磷酸化途径),脂代谢等重要新
陈代谢过程;掌握能量代谢在器官间及细胞内的协调;各器官的能量供求及相互关系。
Through studying this course, students will master the basic process of life metabolism, and master the basic principle
of anabolic metabolism and catabolism; the biochemical reaction energy conversion, the calculation of free energy, the
glycometabolism (including glycolysis, gluconeogenesis, citric acid cycle, oxidative phosphorylation, pentose phosphate
pathway), lipid metabolism, and other important metabolic processes, and grasp the coordination of energy metabolism
in the organs and cells, energy supply and demand of each organ and their interrelation.
17.
课程内容及教学日历 (如授课语言以英文为主,则课程内容介绍可以用英文;如团队教学或模块教学,教学日历须注明
主讲人)
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
3
12 代谢的化学逻辑 学时:2 小时
Chapter 12 Chemical Logic of Metabolism Hours: (2h)
1 代谢路线图概览
1 Metabolic Road Map
2 生化反应类型
2 Biochemical Reaction Types
3 生物热力学概述
3 Some Bioenergetic Considerations
4 代谢调控机理
4 Metabolic Control Mechanisms
5 代谢的实验分析
5 Experimental Analysis of Metabolism
13 糖代谢 学时:5 小时
Chapter 13 Carbohydrate Metabolism Hours: (5h)
1 糖酵解概览
1 Glycolysis: An Overview
2 糖酵解反应过程
2 Reactions of Glycolysis
3 丙酮酸的代谢命运
Metabolic Fates of Pyruvate
4 能量及电子平衡
4 Energy and Electron Balance Sheets
5 糖异生
5 Gluconeogenesis
6 糖代谢通路的进化
Evolution of Carbohydrate Metabolic Pathways
7 糖酵解及糖异生的协同调节
4
Coordinated Regulation of Glycolysis and Gluconeogenesis
8 糖原在肌肉和肝脏中的代谢
8 Glycogen Metabolism in Muscle and Liver
9 戊糖磷酸化途径
9 The Pentose Phosphate Pathway
14 柠檬酸循环及乙醛酸循环 学时:5 小时
14 Citric Acid Cycle and Glyoxylate Cycle Hours: (5h)
1 丙酮酸氧化及柠檬酸循环总览
1 Overview of Pyruvate Oxidation and the Citric Acid Cycle
2 丙酮酸氧化:碳进入柠檬酸循环的主要入口
2 Pyruvate Oxidation: A Major Entry Route for Carbon into the Citric Acid Cycle
3 丙酮酸氧化及柠檬酸循环的辅酶
3 Coenzymes Involved in Pyruvate Oxidation and the Citric Acid Cycle
4 丙酮酸脱氢酶复合物的行动
4 Action of the Pyruvate Dehydrogenase Complex
5 柠檬酸循环
5 The Citric Acid Cycle
6 柠檬酸循环的化学计量学及热力学
Stoichiometry and Energetics of the Citric Acid Cycle
7 丙酮酸脱氢酶及柠檬酸循环的调节
7 Regulation of Pyruvate Dehydrogenase and the Citric Acid Cycle
8 乙醛酸循环
8 Glyoxylate Cycle
15 电子运输,氧化磷酸化,及氧代谢 学时:5 小时 Hours: (5h)
Chapter 15 Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism
1 线粒体
1 The Mitochondrion
5
2 氧化及能量生成
2 Oxidations and Energy Generation
3 电子运输
3 Electron Transport
4 氧化磷酸化
4 Oxidative Phosphorylation
5 线粒体运输系统
5 Mitochondrial Transport Systems
6 氧化代谢的能量生成
6 Energy Yields from Oxidative Metabolism
7 线粒体基因组及疾病
7 The Mitochondrial Genome and Disease
8 线粒体的进化
8 Mitochondria and Evolution
9 氧气作为其它代谢反应的底物
9 Oxygen as a Substrate for Other Metabolic Reactions
16 光合作用 学时:4 小时
Chapter 16 Photosynthesis Hours: (4h)
1 光合作用的基本过程
1 The Basic Processes of Photosynthesis
2 叶绿体
2 The Chloroplast
3 光反应
3 The Light Reactions
4 暗反应:开尔文循环
4 The Dark Reactions: The Calvin Cycle
5 光合作用二系统中光反应及暗反应的总结
5 A Summary of the Light and Dark Reactions in Two-System Photosynthesis