1
课程详述
COURSE SPECIFICATION
以下课程信息可能根据实际授课需要或在课程检讨之后产生变动。如对课程有任何疑问，请
联系授课教师。
The course information as follows may be subject to change, either during the session because of unforeseen
circumstances, or following review of the course at the end of the session. Queries about the course should be
directed to the course instructor.
1.
课程名称 Course Title
生物化学 I（生物大分子） Biochemistry I （Macromolecules）
2.
授课院系
Originating Department
生物系 Department of Biology
3.
课程编号
Course Code
BIO201
4.
课程学分 Credit Value
3
5.
课程类别
Course Type
专业基础课(生物科学、生物技术、生物信息学）
Major Foundational Courses (Biological Sciences, Biotechnology, Bioinformatics)
6.
授课学期
Semester
春季 Spring / 秋季 Fall
7.
授课语言
Teaching Language
英文 English / 中英双语 English & Chinese
8.
授课教师、所属学系、联系方
式（如属团队授课，请列明其
他授课教师）
Instructor(s), Affiliation&
Contact
（For team teaching, please list
all instructors）
生物系：
魏志毅，余聪，杜嘉木
Zhiyi, Wei, Department of Biology, wei.zy@sutsc.edu.cn
Cong,Yu, Department of Biology, yu.c@sustc.edu.cn
Jiamu Du, Department of Biology,dujm@sustech.edu.cn
9.
实验员/助教、所属学系、联系
方式
Tutor/TA(s), Contact
待公布 To be announced
10.
选课人数限额(可不填)
Maximum Enrolment
（Optional）
授课方式
Delivery Method
讲授
Lectures
习题/辅导/讨论
Tutorials
实验/实习
Lab/Practical
其它(请具体注明)
Other（Please specify）
总学时
Total
11.
学时数
Credit Hours
40
6 (including
presentation)
2 (期中考试/mid-term
exam)
48
2
12.
先修课程、其它学习要求
Pre-requisites or Other
Academic Requirements
生物学原理 BIO103，Principles of Biology ；
化学原理 CH101A，General Chemistry A
13.
后续课程、其它学习规划
Courses for which this course
is a pre-requisite
生物化学 II（新陈代谢）BIO202，Biochemistry II (Metabolism)
14.
其它要求修读本课程的学系
Cross-listing Dept.
医学院 Medical School
教学大纲及教学日历 SYLLABUS
15.
教学目标 Course Objectives
生物化学 I（大分子）是的一门生物学基础课程。本课程的目标是为生物学各专业的学生传授生物化学的基本知识和实验方
法。通过课程的学习，让学生能够理解并掌握生物化学的研究对象、研究方法和研究思路，并最终学会应用这些知识和技
巧来解决生物学中的研究问题。
Biochemistry I (Macro-Biomolecules) is a basis course in biology. Our aim is to teach the basic knowledge and
techniques of biochemistry. With this course, we present the biochemical structures, methods, and theories, and teach
students to apply the biochemical knowledge and skills to solve problems in biological research.
16.
预达学习成果 Learning Outcomes
通过本课程的学习，学生可以
1、掌握生物化学中各个反应的基本原理；
2、了解生化分子的结构与功能之间的关系；
3、了解常用的生化技术和方法，并进行生物化学实验设计；
4、分析和解决复杂的生物化学问题。
At the end of the course, students should be able to
1.Demonstrate the basic principal governing the biochemical reactions;
2.Identify the structures of biomolecules and their relationship with functions;
3.Apply common biochemical techniques and skills to design experiments;
4.Analyse and solve complex biochemical problems.
17.
课程内容及教学日历 （如授课语言以英文为主，则课程内容介绍可以用英文；如团队教学或模块教学，教学日历须注明
主讲人）
Course Contents (in Parts/Chapters/Sections/Weeks. Please notify name of instructor for course section(s), if
this is a team teaching or module course.)
3
1. Introduction (6 hours)
1) Brief introduction of biochemistry. (2 hours)
Basis concepts and history of biochemsitry
2) Weak interaction in aqueous system. (2 hours)
Noncovalent interactions
Role of water in biological processes
Interactions between macroions in solution
3) Bioenergetics, basic understanding of thermodynamics in biological systems. (2 hours)
The laws of thermodynamics
Enthalpy, entropy and free energy
Chemical equilibrium and free energy sources in biological systems
2. Nucleic Acids (7 hours)
1) Nucleotides, polynucleotide, and discovery of DNA as genetic material. (2 hours)
Structure and chemical properties of the nucelotides
Primary structure of nucleic acides
2) Double helical structure. (2 hours)
The structural properties of the double helix
Semiconservative nature of DNA replication
Alternative nucleic acid structures (A, B, Z-forms)
3) Structure and function of DNA/RNA (1 hours)
DNA supercoiling
RNA structures
Student Presentation I: Discovery of DNA double helical structure (2 hours)
3. Proteins (15 hours)
1) Amino acids. (1 hour)
Structure of the alpha-amino acids
4
Properties of the amino acid side chains
2) Peptide and secondary structure. (2 hours)
Polyampholytes
The structure and stability of peptide bond
Helices and sheets (Ramachandran plots)
3) Tertiary structure. (3 hours)
Fibrous proteins (Keratin, Fibroin,, and Collagen)
Globular proteins and their classifications
Factors determining secondary and tertiary structure
Protein folding
Dynamics of globular protein structures
4) Quaternary structure. (1 hour)
Protein assembly
Protein-protein interations
5) Protein function and evolution. (4 hours)
Structures of Hemoglobins and myoglobins
Cooperative binding
Allosteric effectors of Hemoglobin
Protein evolution of globins
Hemoglobin variants and diseases
Immunoglobulins and binding vasatility
Mid-term Exam (2 hours)
6) Contractile proteins and molecular motors. (2 hours)
Actin and myosin
The structure of muscle
The mechanism of contraction
Microtubule and intracellular transport
5
4. Enzymes (9 hours)
1) Enzymatic reactions. (2 hours)
Chemical reaction rates and the effects of catalysts
General principles of enzymatic reactions
Examples (Lysozyme and Serine proteases)
2) Enzyme kinetics. (2 hours)
Michaelis-Menten kinetics
The significance of KM, kcat, and kcat/KM
Enzyme inhibition and the changes of KM and kcat,
3) Enzyme regulation. (3 hours)
Cofactors and coenzymes
Classification of enzymes
The regulation of enzyme activity
Allosteric enzymes
Covalent modifications
Student Presentation II: Enzyme structure and function (2 hours)
5. Carbohydrates (4 hours)
1) Monosaccharides and disaccharides (2 hours)
Aldoses and ketoses
Stereoisomers of monosaccharides
Disaccharide structures
Stability and formation of the glycosidic bond
2) Polysaccharides and glycoproteins (2 hours)
Storage and structural polysaccharides
Glycoproteins
Oligosaccharides in different biological structures
6
6. Lipids and membrane (5 hours)
1) Structures of lipids and membrane (2 hours)
Fatty acids, fats, and other derivatives
The major types of lipid constituents of biological membranes
The structure and properties of membranes
2) Membrane proteins and cellular transport (3 hours)
Structures of membrane proteins
The fluid mosaic model of membrane structure
Transport across membrane
Ion channels and action potentials
Tutorial/Review 2 hours
18.
教材及其它参考资料 Textbook and Supplementary Readings
教材/Textbook
Biochemistry, 4th edition, CK Mathews, KE Holde, etc.
参考书/Reference book
Biochemistry，7th edition，Jeremy M. Berg, John L. Tymoczko, Lubert Stryer；
Lehninger Principles of Biochemistry，5th edition，Dave Nelson, Mike Cox
课程评估 ASSESSMENT
19.
评估形式
Type of
Assessment
评估时间
Time
占考试总成绩百分比
% of final
score
违纪处罚
Penalty
备注
Notes
出勤 Attendance
10
课堂表现
Class
Performance
小测验
Quiz
10
作弊 0 分
Cheating, 0
credits
课程项目 Projects
10
平时作业
Assignments
10
抄袭 0 分
Plagiarism, 0
credits
期中考试
Mid-Term Test
30
作弊 0 分
Cheating, 0
credits
7
期末考试
Final Exam
30
作弊 0 分
Cheating, 0
credits
期末报告
Final
Presentation
其它（可根据需要
改写以上评估方
式）
Others (The
above may be
modified as
necessary)
20.
记分方式 GRADING SYSTEM
A. 十三级等级制 Letter Grading
B. 二级记分制（通过/不通过） Pass/Fail Grading
课程审批 REVIEW AND APPROVAL
21.
本课程设置已经过以下责任人/委员会审议通过
This Course has been approved by the following person or committee of authority
本课程经生物系本科教学指导委员会审议通过。
This Course has been approved by Undergraduate Teaching Steering Committee of Department of Biology.
