clinPK-package |
clinPK |
add_ruv |
Add residual variability to data |
as.num |
factors or characters to numeric |
auc2dose |
Convert AUCtau or AUCt to dose (for 1-compartment linear PK model) |
calc_abw |
Calculate adjusted body weight (ABW) |
calc_amts_for_conc |
Calculate the amounts in all compartments in a compartmental PK system based on a given concentration in the central compartment, and assuming steady state. |
calc_bmi |
Calculate BMI |
calc_bsa |
Calculate body surface area |
calc_creat |
Estimate serum creatinine |
calc_creat_neo |
Estimate serum creatinine in neonates |
calc_egfr |
Calculate eGFR |
calc_egfr_cystatin |
Calculate eGFR based on Cystatin C measurements |
calc_ffm |
Calculate fat-free mass |
calc_ibw |
Calculate ideal body weight for children and adults |
calc_kel_single_tdm |
Calculate elimination rate when given a single TDM sample |
calc_lbw |
Calculate lean body weight |
calc_t12 |
Calculate half-life based on two points |
cm2inch |
Convert cm to inch |
conc2mol |
Convert concentration to molar |
convert_creat_assay |
Convert serum creatinine from various assays to Jaffe |
convert_creat_unit |
Convert creatinine to different unit |
dose2auc |
Convert dose to expected AUCinf or AUCt for 1 compartment linear PK model |
find_nearest_dose |
Generic function to calculate the dose nearest to a specific dose unit increment |
find_nearest_interval |
Generic function to calculate the interval nearest to a possible dosing interval |
inch2cm |
Convert inch to cm |
is.nil |
Check if values in vector are empty |
kg2lbs |
Convert kg to lbs |
lbs2kg |
Convert lbs to kg |
mol2conc |
Convert molar to concentration |
nca |
Perform an NCA based on a NONMEM-style dataset |
pct_bmi_for_age |
Percentile BMI for age for children |
pct_for_age_generic |
Percentile height or weight for age for children |
pct_height_for_age |
Percentile height for age for children |
pct_weight_for_age |
Percentile weight for age for children |
pk_1cmt_bolus |
Concentration predictions for 1-compartmental PK model after single or multiple bolus doses |
pk_1cmt_bolus_cmax_ss |
Cmax for linear 1-compartment PK model at steady state, bolus dosing |
pk_1cmt_bolus_cmin_ss |
Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing |
pk_1cmt_bolus_dose_from_cmax |
Calculate dose to achieve steady state Cmax for 1-compartmental PK model bolus dosing at steady state |
pk_1cmt_bolus_dose_from_cmin |
Calculate dose to achieve steady state trough for 1-compartmental PK model bolus dosing at steady state |
pk_1cmt_bolus_ss |
Concentration predictions for 1-compartmental PK model with bolus dosing at steady state |
pk_1cmt_inf |
Concentration predictions for 1-compartmental PK model after single or multiple bolus doses |
pk_1cmt_inf_cmax_ss |
Cmax for linear 1-compartment PK model at steady state |
pk_1cmt_inf_cmin_ss |
Cmin (trough) for linear 1-compartment PK model at steady state |
pk_1cmt_inf_dose_from_cmax |
Calculate dose to achieve steady state Cmax for 1-compartmental PK model with infusion dosing at steady state |
pk_1cmt_inf_dose_from_cmin |
Calculate dose to achieve steady state trough for 1-compartmental PK model with infusion dosing at steady state |
pk_1cmt_inf_ss |
Concentration predictions for 2-compartmental PK model with infusion dosing at steady state |
pk_1cmt_oral |
Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses |
pk_1cmt_t12 |
Calculate terminal half-life for 1-compartment model |
pk_2cmt_bolus |
Concentration predictions for 1-compartmental PK model, single or multiple bolus doses |
pk_2cmt_bolus_cmax_ss |
Cmax for 2-compartmental PK model, bolus dosing at steady state |
pk_2cmt_bolus_cmin_ss |
Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state |
pk_2cmt_bolus_dose_from_cmax |
Calculate dose to achieve steady state Cmax for 2-compartmental PK model bolus dosing at steady state |
pk_2cmt_bolus_dose_from_cmin |
Calculate dose to achieve steady state trough for 2-compartmental PK model bolus dosing at steady state |
pk_2cmt_bolus_ss |
Concentration predictions for 2-compartmental PK model, bolus dosing at steady state |
pk_2cmt_inf |
Concentration predictions for 1-compartmental PK model, single or multiple infusions |
pk_2cmt_inf_cmax_ss |
Cmax (trough) for 2-compartmental PK model, bolus dosing at steady state |
pk_2cmt_inf_cmin_ss |
Cmin (trough) for 2-compartmental PK model, bolus dosing at steady state |
pk_2cmt_inf_dose_from_cmax |
Calculate dose to achieve steady state Cmax for 2-compartmental PK model with infusion dosing at steady state |
pk_2cmt_inf_dose_from_cmin |
Calculate dose to achieve steady state trough for 2-compartmental PK model with infusion dosing at steady state |
pk_2cmt_inf_ss |
Concentration predictions for 1-compartmental PK model with infusion dosing at steady state |
pk_2cmt_t12 |
Calculate half-life(s) for 2-compartment model |
pk_2cmt_t12_interval |
Calculate average half-life for 2-compartment model during a specific interval |
read_who_table |
Internal function to read WHO growth tables from package or download from WHO |
weight2kg |
Convert any weight unit to kg |