Bulk RNA-seq deconvolution by scRNA-seq with multi-reference datasets


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Documentation for package ‘SCDC’ version 0.0.0.9000

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CreateSCDCpropObj Create user-defined SCDC_prop object, as the SCDC_ENSEMBLE input
deconv_simple Simple deconvolution function using W-NNLS
DemoPlot Demographic figure for single cells
generateBulk_allcells Construct Pseudo bulk samples
generateBulk_norep Construct Pseudo bulk samples - random
getCPM0 Normalize matrix / vector
getESET Get ExpressionSet
getSearchGrid Grid search matrix
SCDC_basis Basis Matrix
SCDC_basis_ONE Basis matrix for single cells from one subject
SCDC_ENSEMBLE ENSEMBLE function
SCDC_peval Evaluate deconvolved proportions
SCDC_prop Proportion estimation
SCDC_prop_ONE Proportion estimation function for one-subject case
SCDC_prop_ONE_subcl_marker Tree-guided proportion estimation for ONE subject
SCDC_prop_subcl_marker Tree-guided proportion estimation
SCDC_qc Clustering QC
SCDC_qc_ONE Clustering QC for single cells from one subject
SCDC_yeval Evaluate predicted gene expression levels
wheat_map Heatmap for ENSEMBL weight selection, with four measures
wt_prop Calculate cell type proportions by suggested weights
wt_y Calculate cell type proportions by suggested weights