Efficiently controlling for case-control imbalance and sample
relatedness in single-variant assoc tests (SAIGE) and
controlling for sample relatedness in region-based assoc tests
in large cohorts and biobanks (SAIGE-GENE+)
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Documentation for package ‘SAIGE’ version 1.1.9
Help Pages
| CCT | An analytical p-value combination method using the Cauchy distribution |
| createSparseGRM | Construct a sparse GRM for a given data set |
| fitNULLGLMM | Fit the null logistic/linear mixed model and estimate the variance ratios by randomly selected variants |
| SPAGMMATtest | Run single variant or gene- or region-based score tests with SPA based on the linear/logistic mixed model. |